Publications by authors named "Hanel R"

Numbers of European glass eels (Anguilla anguilla) monitored along the Atlantic and Mediterranean coasts of Europe currently serve as the main stock indicator in assessment of this critically endangered species. Spawning, however, takes place exclusively in the Sargasso Sea, several thousand kilometers away. The beginning of its complex lifecycle is characterized by a distant and lengthy larval drift, before the young-of-the-year reach the monitoring stations at the European coasts.

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The Artisse intrasaccular device (Medtronic) offers a novel treatment option for unruptured and ruptured wide-neck bifurcating intracranial aneurysms.1 2The Artisse device features enhancements including a distal tip for dome protection, platinum band markers for improved visibility, and a bilayer high-density platinum core nitinol mesh basket for enhanced flexibility and visibility when compared with previous devices.2-7 Data from case series demonstrate the procedural safety and efficacy of the Artisse device.

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  • The roundscale spearfish (Tetrapturus georgii) is not well-studied, leading to gaps in knowledge regarding its biology, ecology, and population status.
  • Despite being morphologically distinct from similar species like the white marlin, misidentification complicates population assessments.
  • This study presents the first documented records of a T. georgii egg and juvenile, offering new insights into its reproductive biology and early life stages, emphasizing the need for further research for effective conservation.
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The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation.

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  • This study analyzed decisions regarding decompressive hemicraniectomy (DHC) and early withdrawal of life-sustaining therapy (WLST) in patients with large vessel occlusion (LVO) and large ischemic strokes from the SELECT2 trial.* -
  • Among 352 patients, DHC was utilized in 55 patients, and WLST was chosen for 81, showing no significant differences in usage between those receiving endovascular thrombectomy (EVT) and those treated medically.* -
  • About 21% of DHC patients were able to walk independently after one year, indicating that DHC did not negatively impact the benefits of thrombectomy, while WLST generally resulted in poor outcomes.*
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Background And Objectives: The Woven EndoBridge (WEB) device is a breakthrough in brain aneurysm treatment, widely used for intracranial wide neck and complex aneurysms, especially at bifurcations. Although effective, aneurysm recurrence can occur post-treatment and the impact of clipping angle on the WEB mesh remains unclear. In this study, using a human placenta-based ex-vivo aneurysm model, we simulated the application of aneurysm clipping on WEB-treated aneurysms to elucidate the technical aspects and nuances, particularly the influence of the angle of clip application on WEB collapse.

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Objectives: Moyamoya disease (MMD) is a cerebrovascular disorder marked by the progressive steno-occlusion of the bilateral internal carotid arteries and the formation of abnormal collateral vessel networks at the base of the brain. Previous studies have attempted to identify risk factors predictive of postoperative complications to improve patient management. This study aims to identify pretreatment factors associated with post-bypass symptomatic strokes in MMD patients.

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Background: Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.

Methods: In a prospective, multicenter, interventional, adaptive-design trial, we randomly assigned patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation to undergo middle meningeal artery embolization plus surgery (treatment group) or surgery alone (control group).

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Background: Patients receiving standard treatment for chronic subdural hematoma have a high risk of treatment failure. The effect of adjunctive middle meningeal artery embolization on the risk of treatment failure in this population remains unknown.

Methods: We randomly assigned patients with symptomatic chronic subdural hematoma to undergo middle meningeal artery embolization as an adjunct to standard treatment (embolization group) or to receive standard treatment alone (control group).

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Background: The EXCELLENT registry aimed to evaluate the effectiveness of the EMBOTRAP Revascularization Device in an all-comer population in a real-world setting, with a focus on the composition of retrieved clots.

Methods: EXCELLENT is a prospective, global registry of patients with acute ischemic stroke treated with EMBOTRAP as the first-line mechanical thrombectomy device conducted at 34 sites (25 sites contributing clot) from September 2018 to March 2021, utilizing core imaging and central histology laboratories blinded to clinical data, independent 90-day modified Rankin Scale assessment and Clinical Events Committee.

Results: After screening 3799 patients, a total of 997 subjects (mean age, 70.

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  • Heavily calcified carotid stenosis (HCCS) has traditionally been challenging to treat with carotid angioplasty and stenting (CAS), but this study explores the use of the Shockwave S intravascular lithotripsy (IVL) system as a potential solution.
  • A retrospective analysis of 17 procedures combining IVL and CAS on patients with HCCS showed technical success in all cases and significant reductions in stenosis levels post-procedure.
  • The results indicated that the combined approach is safe, with a low major adverse event (MAE) rate and a promising outcome in managing both symptomatic and asymptomatic patients with HCCS.
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  • Endovascular thrombectomy (EVT) has proven safe and effective for patients suffering from large core strokes, but the effects of reperfusion quality and procedure details on outcomes are still unclear.
  • In the SELECT2 trial, findings indicated that 80% of patients experienced successful reperfusion, which correlates with better clinical outcomes, particularly in those who achieved near-complete reperfusion.
  • Longer procedure times negatively impacted patient outcomes, while the method of thrombectomy (aspiration vs stent-retriever) showed no significant differences in reperfusion success or functional recovery.
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Social and biological collectives exchange information through internal networks to function. Less studied is the quantity and variety of information transmitted. We characterize the information flow into organizations, primarily business firms.

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Background And Objectives: Multiple preferences exist for embolic materials selection in middle meningeal artery embolization (MMAE) for chronic subdural hematoma with limited comparative literature data. Herein, we compare different embolic materials.

Methods: Consecutive patients undergoing MMAE for chronic subdural hematoma at 14 North-American centers (2018-2023) were classified into 3 groups: (a) particles, (b) Onyx, (c) n-butyl cyanoacrylate (n-BCA).

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Background And Objectives: Moyamoya disease (MMD) is characterized by progressive steno-occlusion of the internal carotid arteries, leading to compensatory collateral vessel formation. The optimal surgical approach for MMD remains debated, with bilateral revascularization potentially offering more comprehensive protection but involving more extensive surgery compared to unilateral revascularization. This study aims to compare bilateral revascularization and unilateral revascularization short-term safety profile in the treatment of MMD.

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Background: Flow diversion has revolutionized the management of wide-necked intracranial aneurysms (IAs). We aimed to assess the effectiveness and safety of the new generation 64-wire Surpass Evolve for the treatment of unruptured small/medium-sized IAs.

Methods And Results: This is a subanalysis from the SEASE (Safety and Effectiveness Assessment of the Surpass Evolve) registry, an observational cohort study including 15 academic institutions in North America and Europe between July 2020 and October 2022.

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  • Steal syndrome occurs when blood flow is redirected through collateral vessels due to an obstruction in an artery, which can lead to conditions like subclavian steal syndrome and double steal phenomenon.
  • A case study presented involves an elderly patient suffering from cerebrovascular issues who experienced neurological symptoms while chewing, linked to specific artery blockages discovered via angiography.
  • Successful treatment was achieved by performing endovascular revascularization on the affected arteries using a specialized stent, which resolved the patient’s symptoms.
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  • The study examines the stability of the Pipeline Embolization Device (PED) in treating brain aneurysms, focusing on early generations and potential braid deformations.
  • Data was gathered from the PREMIER trial, reviewing 133 out of 141 aneurysms for issues like braid bumping and foreshortening, assessing both safety and effectiveness.
  • The results show that while a small percentage experienced braid deformations, they didn't significantly impact the device's safety or effectiveness over the follow-up period.
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Objective: To determine the effect of tranexamic acid (TXA) on clot hyperfibrinolysis (HF), defined as excessive clot lysis at 30 minutes (LY30%), with rapid thromboelastography (rTEG) or rTEG samples spiked with tissue plasminogen activator (tPA-stressed rTEG), in dogs with hemorrhagic shock.

Methods: Prospective blinded clinical trial at 2 teaching hospitals, March 16, 2018, to May 20, 2022. Twenty-five dogs with hemorrhagic shock and HF were treated with standard care plus either TXA (20 mg/kg; TXA group) or saline (SAL group) over 20 minutes followed by an infusion of the same dose over 8 hours.

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  • - Moyamoya disease (MMD) is a rare brain disorder that causes narrowing of blood vessels, often accompanied by high blood pressure, which complicates the condition's outcomes; this study compares MMD patients with and without hypertension.
  • - A total of 598 MMD patients were analyzed from multiple institutions, with hypertensive (292) and non-hypertensive (306) groups evaluated for clinical characteristics and outcomes using statistical adjustments to account for differences in their backgrounds.
  • - Results indicated that although hypertensive patients showed higher rates of certain risk factors (like diabetes and smoking) and higher stroke rates before adjustments, post-matching analysis revealed no significant differences in stroke rates or recovery outcomes between the two groups, suggesting effective
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Background: This study aims to address the safety and efficacy of mechanical thrombectomy (MT) in acute ischemic stroke with an established infarction equal to or >50 mL with a significant difference between penumbra and established infarction detected by perfusion cerebral computed tomography (CT) with the Rapid system.

Methods: This was a retrospective case-control study. Patients diagnosed with established and extensive ischemic stroke, defined by an ischemic volume equal to or >50 mL on CT or magnetic resonance imaging perfusion using the RAPID system, were examined.

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Background: Treatment of large vessel occlusion (LVO) using mechanical thrombectomy with or without intravenous thrombolysis has demonstrated better outcomes compared to medical treatment alone. Large-bore aspiration catheters have been recently introduced. Their effectiveness and safety have not been demonstrated in a randomized trial.

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Background: The optimal duration for dual antiplatelet therapy (DAPT) after stent-assisted coiling (SAC) of intracranial aneurysms is unclear. Longer-term therapy may reduce thrombotic complications but increase the risk of bleeding complications.

Methods: A retrospective review of prospectively maintained data at 12 institutions was conducted on patients with unruptured intracranial aneurysms who underwent SAC between January 1, 2016 and December 31, 2020, and were followed ≥6 months postprocedure.

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  • The study investigates the impact of decompressive craniectomy (DC) on patients with symptomatic intracerebral hemorrhage (sICH) following acute ischemic stroke, comparing outcomes between those who had surgery and those treated medically.
  • It analyzed data from 85 patients across 8 stroke centers, revealing that DC patients were younger, had longer ICU stays, and showed better functional outcomes at 90 days compared to non-DC patients, especially if they were younger and did not have a history of cancer.
  • The results indicate that the DC group had lower in-hospital mortality rates and came out with improved scores on the modified Rankin Scale, suggesting a potential benefit of surgery for select patients with severe sICH.
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