Establishment of a value assessment framework for orphan medicinal products in China.

Background: This study aimed to establish a suitable value assessment framework for orphan medicinal products in China based on the multi-criteria decision analysis (MCDA) method.

Methods: First, a draft framework of the MCDA criteria was built based on a systematic literature evaluation and the EVIDEM framework tools. Second, stakeholder groups were formed and expert opinions were collected through the brainstorming and expert consultation methods.

The impact of preoperative MRI-detected lateral meniscal intra-substance signal abnormalities on mid-term functional outcomes following mobile-bearing unicompartmental knee arthroplasty.

Purpose: There is a dilemma as to whether the presence of degenerative changes of lateral meniscus is a contraindication to medial unicompartmental knee arthroplasty (UKA). Therefore, the purpose of this study is to assess the influence of preoperative MRI-detected lateral meniscal intra-substance signal abnormalities on mid-term functional outcomes following mobile-bearing UKA.

Methods: We performed a retrospective review of the record on a consecutive series of patients who have undergone mobile-bearing medial UKA from September 2020 to June 2023.

Predicting valgus malalignment after mobile-bearing UKA using a new method: the arithmetic HKA of the arthritic knee.

Background: Valgus malalignment is one of the most common reasons for the progression of osteoarthritis in the lateral compartment of the knee after mobile-bearing unicompartmental knee arthroplasty (UKA). The arithmetic hip-knee-ankle angle (aHKA) of the Coronal Plane Alignment of the Knee (CPAK) classification could reflect the constitutional alignment of the arthritic knee. The purpose of this study was to observe the relationship between the aHKA and valgus malalignment after mobile-bearing UKA.

[High tibial osteotomy combined with lateral retinacular release for the treatment of knee varus osteoarthritis with lateral patellar compression syndrome].

Objective: To investigate the clinical effect of high tibial osteotomy combined with arthroscopic lateral retinacular release in the treatment of knee varus osteoarthritis.

Methods: From October 2017 to April 2019, a retrospective analysis was performed on 43 patients with knee varus osteoarthritis and lateral patellar compression syndrome treated by high tibial osteotomy combined with arthroscopic lateral retinacular release. There were 15 males and 28 females, aged 53 to 72(62.

The effect of distal tibial tuberosity high tibial osteotomy on postoperative patellar height and patellofemoral joint degeneration.

Background: Distal tibial tuberosity high tibial osteotomy (DTT-HTO) can prevent distalization of the tibial tuberosity and thus patellar infera. However, no studies on the clinical and radiological effects of DTT-HTO on the patellofemoral joint have been conducted. The purpose of the study was to evaluate the effect of DTT-HTO on patella height and patellofemoral joint congruity based on the severity of patellofemoral joint OA.

Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.

The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research. In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites. Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.

[Evaluation of cartilage regeneration by arthroscopy after high tibial osteotomy].

Objective: To evaluate the cartilage regeneration in the knee joint by arthroscopy after high tibial osteotomy.

Methods: Eleven patients were included in the study who were treated with high tibial osteotomy and underwent microscopy when the internal fixation was unloaded from September 2017 to September 2019. Among them, there were 2 males and 9 females, aged from 55 to 64 years old.

[High tibial osteotomy combined with arthroscopy for elderly patients with knee osteoarthritis of medial compartment].

Objective: To observe early clinical effect of high tibial osteotomy combined with arthroscopy for elderly patients with knee osteoarthritis of medial compartment.

Methods: Sixty-one elderly patients with medial compartment knee osteoarthritis were treated with high tibial osteotomy combined with arthroscopy from August 2017 to October 2018. Among them, including 17 males and 44 females, aged from 60 to 83 years old with an average of (67.

Distal tibial tuberosity high tibial osteotomy using an image enhancement technique for orthopedic scans in the treatment of medial compartment knee osteoarthritis.

Objective: To observe the efficacy of distal tibial tuberosity high tibial osteotomy in treating medial compartment osteoarthritis of the knee. In the experiment, a medical image enhancement algorithm based on shear wave domain improved Gamma correction was implemented to process medical images in order to diagnose patients more effectively.

Methods: Sixty-five patients (13 males and 52 females) were included in the study who were treated with distal tibial tuberosity high tibial osteotomy, and the mean age of the patients was 63±6 years (range 49-73).

Medical imaging and diagnosis of subpatellar vertebrae based on improved Laplacian image enhancement algorithm.

Objective: Nowadays, arthroscopy is widely applied to the treatment of joint diseases. The experimental trials were designed to determine whether the infrapatellar plica was symptomatic or not, and to appraise the medical effects of these patients who underwent arthroscopic treatment. An improved Laplacian image enhancement algorithm is added to the experiment.

[Clinical applications of the neurocutaneous axial flap pedicled with perforating vessels].

Objective: To report the operative technique and clinical results of the neurocutaneous vascular axial flap with perforating vessels as its pedicle.

Methods: An axial skin flap was designed along the axis of small paraneural vessels that was close to a concomitant cutaneous nerve. The cutaneous perforating branches of major arteries were used as the pedicle, which provided a rotation arc for the flap to cover the defects in the distal site of extremities.

Magic doping fractions for high-temperature superconductors.

We report hole-doping dependence of the in-plane resistivity rho(ab) in a cuprate superconductor La(2-x)Sr(x)CuO4, carefully examined using a series of high-quality single crystals. Our detailed measurements find a tendency towards charge ordering at particular rational hole-doping fractions of 1/16, 3/32, 1/8, and 3/16. This observation appears to suggest a specific form of charge order and is most consistent with the recent theoretical prediction of the checkerboard-type ordering of the Cooper pairs at rational doping fractions x = (2m+1)/2n, with integers m and n.

Pair density wave in the pseudogap state of high temperature superconductors.

Recent scanning tunneling microscopy experiments of Bi(2)Sr(2)CaCu(2)O(8+delta) have shown evidence of real-space organization of electronic states at low energies in the pseudogap state [Science 303, 1995 (2004)]]. We argue based on symmetry considerations as well as model calculations that the experimentally observed modulations are due to a density wave of d-wave Cooper pairs without global phase coherence. We show that scanning tunneling microscopy measurements can distinguish a pair density wave from more typical electronic modulations such as those due to charge density wave ordering or scattering from an on site periodic potential.

Quantitative test of SO(5) symmetry in the vortex state of Nd(1.85)Ce(0.15)CuO4.

By numerically solving models with competing superconducting and antiferromagnetic orders, we study the magnetic field dependence of the antiferromagnetic moment in both the weak and strong field regimes. Through a comparison with the neutron scattering results of Kang et al. and Matsuura et al.

Antiferromagnetism and hole pair checkerboard in the vortex state of high T(c) superconductors.

We propose a microscopic state for the vortex phase of BSCO superconductors. Around the vortex core or above H(c2), the d wave hole pairs form a checkerboard localized in the antiferromagnetic background. We discuss this theory in connection with recent STM experiments.