Upgrading the Bioactive Potential of Hazelnut Oil Cake by under Solid-State Fermentation.

Hazelnut oil cake (HOC) has the potential to be bioactive component source. Therefore, HOC was processed with a solid-state fermentation (SSF) by with two steps optimization: Plackett-Burman and Box-Behnken design. The variables were the initial moisture content (X: 30-50%), incubation temperature (X: 26-37 °C), and time (X: 3-5 days), and the response was total peptide content (TPC).

Celery Root Phenols Content, Antioxidant Capacities and Their Correlations after Osmotic Dehydration in Molasses.

The osmotic dehydration (OD) of celery root in sugar beet molasses was studied at three temperatures (20, 35, and 50 °C) and three immersion periods (1, 3, and 5 h) in order to examine the changes in antioxidant potential and phenolic profile of celery root throughout the process. The antioxidant capacity (AOC) of dehydrated samples was evaluated by spectrophotometric and polarographic assays, the total phenolic content by the Folin-Ciocalteu method, and the individual phenolic compounds by HPLC-DAD. As a result of OD in molasses, the AOC and phenols content in samples increased proportionally to the augmentation of temperature and the immersion time.

Effect of ultrasonication and vacuum impregnation pretreatments on the quality of beef marinated in onion juice a natural meat tenderizer.

This study aimed to determine the effect of ultrasonication (US) and vacuum impregnation (VI) pretreatment techniques applied for the improvement of tenderness on the quality of beef () traditionally marinated (TM) in onion juice by immersion. TM conditions were 1:5 meat to marinade ratio, final NaCl concentration of 9% (w/v), 4.3 °C and 24 h.

Characterization of carboxymethyl cellulose-based antimicrobial films incorporated with plant essential oils.

The aim of this study was to investigate the effect of essential oil (EO) addition (1, 2, and 3% v/v) obtained from different plants (Santolina chamaecyparissus (SC), Schinus molle (SM), and Eucalyptus globulus (EG) on the antimicrobial, physical, water vapor permeability, mechanical, optical and microstructural properties of the carboxymethyl cellulose (CMC) films. The films containing EO at the concentration of 3% showed the highest antimicrobial activity on tested microorganisms. The EO content increase from 1% to 3% in films decreased the moisture content and water solubility of all films.

Effect of batch and continuous thermosonication on the microbial and physicochemical quality of pumpkin juice.

The study investigated the use of batch and continuous thermosonication for pasteurization of pumpkin () juice emphasizing on its microbial, physicochemical and sensorial quality parameters. Batch thermosonication (40, 50, 60 °C, 37 kHz, 150 W) of pumpkin juice was compared with the ultrasonication (23 °C) and conventional heat treatments (40, 50, 60 °C). For batch thermosonication, maximum inactivation of K-12 was 6.

Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas.

Introduction: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumor features and reduced responsiveness to somatostatin analogues. AIP is a regulator of Ga signaling, but it is not known how the biological function of the Ga pathway is controlled.

Aim: To study GNAS and AIP mutation status, AIP and Ga protein expressions, Ki-67 proliferation indices and clinical parameters in patients having primary surgery because of acromegaly at a single center between years 2000 and 2010.

Effect of physicochemical parameters on the polygalacturonase of an Aspergillus sojae mutant using wheat bran, an agro-industrial waste, via solid-state fermentation.

Background: Polygalacturonases (PGs) are valuable enzymes of the food industry; therefore it is of great importance to discover new and GRAS PG-producing microbial strains. In this study, PG enzyme produced from a high PG activity producer mutant Aspergillus sojae using wheat bran at the flask scale under pre-optimized conditions of solid-state fermentation (SSF) was biochemically characterized.

Results: The crude PG enzyme showed optimum activity in the pH range 4.

Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas.

Context: The somatic landscape of pituitary adenomas is largely unknown. Identification of somatic alterations aims at better understanding of tumor pathology.

Objective: The objective of the study was a genome-wide characterization of somatic single-nucleotide variants, structural variants, and copy-number aberrations in somatotropinomas.

Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.

Pituitary adenomas are neoplasms of the anterior pituitary lobe and account for 15-20% of all intracranial tumors. Although most pituitary tumors are benign they can cause severe symptoms related to tumor size as well as hypopituitarism and/or hypersecretion of one or more pituitary hormones. Most pituitary adenomas are sporadic, but it has been estimated that 5% of patients have a familial background.

A report on the use of Er:YAG laser for pilot hole drilling prior to miniscrew insertion.

The aim of the present in vitro study was to investigate the required time period of the Er:YAG laser that is used for drilling through cortical bone when pilot hole drilling is needed before miniscrew insertion. Even though Er:YAG laser is used in various in vivo and in vitro studies, there is no accepted procedure of laser for depth control during drilling through cortical bone. The study sample consisted of 120 cortical bone segments having 1.