Publications by authors named "Handattu S Akshatha"
J Enzyme Inhib Med Chem
December 2024
Article Synopsis
- - The study focuses on inhibiting DprE1, a crucial enzyme in the synthesis of cell wall components in mycobacteria, which include the bacteria causing tuberculosis.
- - Researchers synthesized and tested 15 new compounds targeting DprE1, with two compounds (BOK-2 and BOK-3) showing promising inhibition at low concentrations (IC values of 2.2 and 3.0 μM, respectively).
- - The research utilized molecular modeling to understand how these compounds interact with DprE1, paving the way for potential new treatments for tuberculosis through targeted drug design.
