Publications by authors named "Hanbo Tan"
Article Synopsis
- * A new modified method, called m-EAI, effectively speeds up the drainage of interstitial fluid and reduces harmful inflammatory substances in the brain following a stroke.
- * Results from a study using a rat model show that m-EAI led to lower levels of key inflammatory markers and improved outcomes in terms of brain damage and recovery, suggesting it could be a promising strategy for treatment alongside other neuroprotective therapies.
[Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2024
Objective: To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ.
Methods: Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na).
The brain extracellular space (ECS), an irregular, extremely tortuous nanoscale space located between cells or between cells and blood vessels, is crucial for nerve cell survival. It plays a pivotal role in high-level brain functions such as memory, emotion, and sensation. However, the specific form of molecular transport within the ECS remain elusive.
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