Publications by authors named "Hanane M'Hamdi"
Article Synopsis
- Oral administration of antigens (Ag) triggers regulatory T cells that carry latent TGF-β, crucial for oral tolerance development.
- An in vitro study showed that specific antibodies and IL-2 can promote latent membrane-bound TGF-β expression on naive CD4 T cells without needing Foxp3 or external TGF-β.
- Pro-inflammatory cytokines like IL-6 hinder the induction of these regulatory T cells, suggesting that targeting the IL-6 pathway might improve oral tolerance and help manage autoimmune conditions.
Article Synopsis
- γδ T cells are a specialized type of lymphocyte that help protect the body from infections and tumors.
- A specific subset of these cells, which express the latency-associated peptide (LAP), migrates to the intestines and alters their functioning, taking on a regulatory role.
- These TCRγδ+LAP+ cells can present antigens and promote the development of other regulatory T cells, offering insights into immune regulation and intestinal health.
Article Synopsis
- Fetal cells enter the maternal bloodstream during pregnancy, leading to a condition called microchimerism, where these cells persist for decades and may influence maternal health and tissue repair.
- Researchers tested the theory that the fetal microchimeric cells are primitive stem cells, specifically CD34+ adherent cells, found in the blood of pregnant women.
- The study found a significant presence of these fetal cells in the adherent CD34+ cell population and identified markers indicating their stem cell characteristics, suggesting they could sustain a long-term fetal presence in the mother's body.
Article Synopsis
- A Phase I study was conducted to evaluate the safety of injecting patients with liver insufficiency with their own CD34(+) stem cells, which were believed to have regenerative potential.
- The CD34(+) cells were separated into two groups based on their adherence to culture plastic, showing distinct characteristics that suggested some could differentiate into various tissue types, including liver cells.
- Following the injections, no serious complications occurred, and some patients showed improved liver function markers, indicating the need for further research.
