Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo Distribution.

Background: Itraconazole (ITZ) is an antiangiogenic agent recognized as a potent suppressor of endothelial cell growth that suppresses angiogenesis. Nevertheless, its exploitation is significantly restricted by its low bioavailability and systematic side effects. The objective of this study was to utilize glycerosomes (GLY), glycerol-developed vesicles, as innovative nanovesicles for successful ITZ pulmonary drug delivery.

Phytochemical Characterization Utilizing HS-SPME/GC-MS: Exploration of the Antioxidant and Enzyme Inhibition Properties of Essential Oil from Saudi L.

This study aimed to analyze the chemical composition and biological activities of L. essential oil, focusing on its antioxidant and enzyme inhibition (α-amylase and urease) properties. Additionally, in vitro pharmacokinetic and pharmacodynamic evaluations were conducted through in silico molecular docking and BOILED-Egg models to assess its therapeutic potential and its potency in treating oxidative-stress-related diseases.

Anti-Alzheimer's Potency of Rich Phenylethanoid Glycosides Extract from L.: In Vitro and In Silico Studies.

Background/objectives: L. (. ), the white horehound, is well known for treating inflammation-related diseases.

Exploring the therapeutic potential of Saudi (L.) DC. Essential oil: Insights into antioxidant, analgesic, and hepatorenal protective effects.

Lately, the herb's essential oils have received the intense attention of researchers and pharmaceutical agencies. The chemical composition, antioxidant, analgesic activity, anti-hyperpyrexia, and hepatorenal protective effects of the (L.) DC.

New Glycotoxin Inhibitor from Mitigates Symptoms of Insulin Resistance and Diabetes by Suppressing AGE-RAGE Axis in Skeletal Muscle.

The current study intended to investigate the role of new natural compounds derived from the plant in mitigating symptoms of diabetes and insulin resistance in the diabetic mice model. Anti-advanced glycation activity, insulin, and adiponectin were quantified by enzyme-linked immunosorbent assay (ELISA). Glucose uptake was performed using enzymatic fluorescence assay, and glycogen synthesis was measured using PAS staining.

Green synthesized extracts/Au complex of : Unrevealing the anti-cancer and anti-bacterial potentialities, supported by metabolomics and molecular modeling.

The anti-cancer and anti-bacterial potential of the Red Sea sponge in its bulk (crude extracts) and gold nanostructure (loaded on gold nanaoparticles) were investigated. Metabolomics analysis was conducted, and subsequently, molecular modeling studies were conducted to explore and anticipate the secondary metabolites and their potential target for their various bioactivities. The chloroformic extract (CE) and ethyl acetate extract (EE) of the predicted to include bioactive lipophilic and moderately polar metabolites, respectively, were used to synthesize gold nanoparticles (AuNPs).

Phytochemical characterization of (lucky nut) bark extracts by GC-MS analysis, along with evaluation of its biological activities, and molecular docking study.

Thevetia peruviana (T. peruviana; Family: Apocynaceae), commonly known as Lucky Nut, is a traditionally and medicinally important plant, and the barks of the plant are traditionally used as anti-inflammatory, anti-diabetic, and antibacterial remedies. Thus, this study aimed to evaluate bioactive phytochemicals and -vitro biological activities from the bark of T.

Phytochemical analysis and bioactivity assessment of five medicinal plants from Pakistan: Exploring polyphenol contents, antioxidant potential, and antibacterial activities.

Plants have always been the prime focus in medicine industries due to their enormous ethnobotanical uses and multitude of biological and therapeutic properties. In the current study, preliminary phytochemical composition, Total phenolic content (TPC), and total flavonoid content (TFC) with the antioxidant and antibacterial activity of hydroalcoholic extract and n-hexane, chloroform and n-butanol fractions of five selected medicinal plants [ (L.) Pers.

Antiarthritic potential of the butanol fraction of : An , , and evaluation.

(Fenzl) Verdc (Aizoaceae) has been traditionally used in the treatment of inflammation, arthritis, and gout. However, its antiarthritic potential has not been evaluated scientifically. The current study was designed to assess the antiarthritic properties of the -butanol fraction of (SsBu) by phytochemical analysis, and pharmacological activities, and studies.

A detailed biochemical characterization, toxicological assessment and molecular docking studies of : An important medicinal xero-halophyte.

(Asso) Pau (Family: Asteraceae) is a wild medicinal plant that has been used in the folklore as a potential treatment for numerous ailments such as skin diseases, diarrhea, infected wounds, inflammation, child fever and hepatic pain. This study explored the chemical constitution, toxicity, antimicrobial, antioxidant, and enzyme inhibition potential of ethanolic extract of (EELF). Additionally, docking studies of predominant compounds were performed against tested enzymes.

Chemical Characterisation, Antidiabetic, Antibacterial, and In Silico Studies for Different Extracts of (Boiss.) Benth: A Promising Halophyte.

The objective of the study is to evaluate the chemical characterisation, and biological and in silico potential of (Boiss.) Benth, an important halophyte commonly used in traditional medicine. The research focuses on the roots and aerial parts of the plant and extracts them using two solvents: methanol and dichloromethane.

Voriconazole Cyclodextrin Based Polymeric Nanobeads for Enhanced Solubility and Activity: In Vitro/In Vivo and Molecular Simulation Approach.

Hydroxypropyl β-cyclodextrin (HPβCD) based polymeric nanobeads containing voriconazole (VRC) were fabricated by free radical polymerization using '-methylene bisacrylamide (MBA) as a cross-linker, 2-acrylamide-2-methylpropane sulfonic acid (AMPS) as monomer and ammonium persulfate (APS) as reaction promoter. Optimized formulation (CDN5) had a particle size of 320 nm with a zeta potential of -35.5 mV and 87% EE.

Headspace Solid Phase Micro-Extraction of Volatile Constituents Produced from Saudi and Molecular Docking Study of Potential Antioxidant Activity.

L., commonly known as Shazab in Saudi Arabia, is one of the famous culinary plants belonging to the Rutaceae family. It is commonly used in ethnomedicine in treating numerous diseases.

Evaluation of the anti-inflammatory, antioxidant, and cytotoxic potential of L. (Brassicaceae): A comprehensive biochemical, toxicological, and computational study.

L. (Brassicaceae) is an important edible plant with ethnomedicinal significance. This study aimed at evaluating the phytochemical composition, anti-inflammatory, antioxidant and cytotoxicity aspects of the hydro-alcoholic extract of (HAECA).

Chemical Composition of Flowers Essential Oil and Hepato-Therapeutic Effect against Carbon Tetrachloride-Induced Toxicity (In-Vivo).

The liver is a crucial organ among body organs due to its wide functions, in particular, detoxification and metabolism. Exposure to detrimental chemicals or viral infections may provoke liver dysfunction and ultimately induce liver tissue damage. Finding natural substances for liver disease treatment to overcome the conventional treatments' side effects has attracted the attention of researchers worldwide.

Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking.

COVID-19 is a disease caused by the coronavirus SARS-CoV-2 and became a pandemic in a critically short time. Phenolic secondary metabolites attracted much attention from the pharmaceutical industries for their easily accessible natural sources and proven antiviral activity. In our mission, a metabolomics study of the Roxb.

Phytochemical Profiling, In Vitro Biological Activities, and In-Silico Studies of : An Unexplored Plant.

Forssk. (Moraceae family) is an important medicinal plant that has not been previously investigated for its phytochemical and biological potential. Phytochemical screening, total bioactive content, and GCMS analysis were used to determine its phytoconstituents profile.

Efficacy of Phytochemicals Derived from Roots of as Antioxidant, Antiulcer, Diuretic, Skin Brightening and Hemolytic Agents-A Comprehensive Biochemical and In Silico Study.

Roots of are a rich source of phytochemicals with high antioxidant potential and thus may possess health benefits. This study used the LC-MS technique to identify phytoconstituents in roots extract/fractions. Results revealed that -butanol fraction and ethanolic extract contained total phenolic and flavonoid contents with values of 155.

Euphocactoside, a New Megastigmane Glycoside from Growing in Saudi Arabia.

A phytochemical investigation of the aerial parts of Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (), along with eleven known metabolites.

Headspace solid-phase microextraction method for extracting volatile constituents from the different parts of Saudi L. and their antimicrobial activity.

L. is a famous aromatic herb that is widely used as a spice and has been applied in folk medicine to cure many diseases. The current work was carried out to compare the chemical composition and antimicrobial potency of essential oils obtained from the different parts of Saudi .

Phytochemical Profiling, In Vitro Biological Activities, and In Silico Molecular Docking Studies of .

, a traditionally significant medicinal plant, has not been extensively explored before for its phytochemical and biological potential. The present study was conducted to evaluate the bioactive phytochemicals and in vitro biological activities of , and perform in silico molecular docking validation of . The bioactive phytochemicals were assessed by preliminary phytochemical testing, total bioactive contents, and GC-MS analysis.

Phytochemical Analysis of Leaves: Identification of Garcinamines F-H and Their Antiproliferative Activities.

is a medicinal plant used in the Arab region for intestinal diseases, lung and liver diseases, digestive problems, and as an antidiabetic agent. Repeated chromatographic purifications of leaves led to the isolation of three undescribed guaiane sesquiterpene derivatives, named garcinamines F-H, characterized by the presence of an amino acid unit, along with five known sesquiterpene lactones (garcinamines B-E and 9β-hydroxyparthenolide). The structures of the new compounds were established using spectroscopic (1D and 2D NMR) and spectrometric methods (ESIMS).

Sterols and Triterpenes from Growing in Saudi Arabia and Their Cytotoxic Activity.

A new lupane caffeoyl ester, lup-20(29)-ene 3β-caffeate-30-al (), and a new oleanane-type triterpene, 3-hydroxyolean-13(18)-en-12-one (), were isolated from the aerial parts of (Forssk), along with ten known triterpenes, including seven lupane-type lupeol (), 30-nor-lup-3-ol-20-one (), ∆-lupenone (), lup-20(29)-en-3,30-diol (), lupeol caffeate (), 30-hydroxy lup-20(29)-ene 3-caffeate (), and betunaldehyde (); three oleanane-type compounds were also identified, comprising -amyrone (), -amyrin (), and 11-oxo--amyrin (); together with six sterols, comprising -sitosterol (), stigmasterol (), 7-hydroxy--sitosterol (), 7-hydroxy-stigmasterol (), 7-keto--sitosterol (), and 7-keto-stigmasterol (). Their structures were elucidated using a variety of spectroscopic techniques, including 1D (H, C, and DEPT-135 C) and 2D (H-H COSY, H-C HSQC, and H-C HMBC) nuclear magnetic resonance (NMR) and accurate mass spectroscopy. Subsequently, the different plant extracts and some of the isolated compounds (, and ) were investigated for their possible cytotoxic activity in comparison to cisplatin against a wide array of aggressive cancer cell lines, such as colorectal cancer (HCT-116), hepatocellular carcinoma (HepG-2), and prostate cancer (PC-3) cell lines.

Coronavirus nCOVID-19: A pandemic disease and the Saudi precautions.

Now nCOVID-19 has a foothold in many countries, and the threat of a pandemic situation has risen. Recently a novel coronavirus (nCOVID-19) has first emerged in China, causing multiple symptoms in humans and closely related to those caused by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). The nCOVID-19 has reported in Wuhan city of China has recently infected over six million people and at least 0.