The Expression of PDL-1 and PD1 in the Microenvironment of Oral Squamous Cell Carcinoma.

Objective: Immune checkpoint proteins, especially PD-1/PD-L1, play a vital role in controlling the intensity and duration of the immune response. However, cancer cells often over-expression PDL-1 on their surfaces, which leads to the permanent activation of the PD-1/PDL-1 pathway and exhaustion of T cells and creates a resistant tumor microenvironment. This study aimed to analyze PD-1, PD-L1 expression in tumor cells (PDL-1/TC) and in Tumor-Infiltrating Lymphocytes (PDL-1/TILS) of OSCC patients and associated with and to correlate it with histologic grade of malignancy and clinicopathologic parameters.

Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis.

Objective: This study aimed to analyze CD4 +and CD8 + TILs in oral squamous cell carcinoma (OSCC) and to correlate it with histologic grade of malignancy and clinicopathologic data.

Methods: The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained.