Publications by authors named "Hanan Ehtewish"
Background: Dementia is a debilitating neurological disease affecting millions of people worldwide. The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for the role of immune dysregulation in the pathogenesis of dementia, where blood-borne autoimmune antibodies have been studied as potential markers associated with pathological mechanisms of dementia.
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- - Autism spectrum disorder (ASD) is a neurodevelopmental condition with varying symptoms, primarily affecting social/communication skills and causing repetitive behaviors, with no approved diagnostic biomarker currently available.
- - This study analyzed serum samples from 93 ASD cases and 28 healthy controls to identify autoantibodies associated with ASD using advanced protein-array technology, resulting in the discovery of 29 differential autoantibodies.
- - The findings suggest that these autoantibodies are linked to essential brain functions, such as axonal guidance and metabolic pathways, and their expression varies with the age of individuals diagnosed with ASD.
Article Synopsis
- Dementia is a serious neurological disorder that affects many people, and there's a crucial need to find reliable, minimally invasive biomarkers for early diagnosis and treatment.
- This study examined blood samples from 122 participants to identify proteins associated with dementia, finding that 61 proteins were dysregulated in dementia patients compared to healthy controls, and 17 biomarkers could differentiate dementia with high accuracy.
- The research suggested that immune response and vascular injury pathways are involved in dementia's development, highlighting potential targets for future studies and treatments.
Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with repetitive and restrictive behaviors or interests. Thus far, there are no approved biomarkers for ASD screening and diagnosis; also, the current diagnosis depends heavily on a physician's assessment and family's awareness of ASD symptoms.
View Article and Find Full Text PDFCognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD), and other forms of dementia are recognized as common comorbidities of type 2 diabetes mellitus (T2DM). Currently, there are no disease-modifying therapies or definitive clinical diagnostic and prognostic tools for dementia, and the mechanisms underpinning the link between T2DM and cognitive dysfunction remain equivocal. Some of the suggested pathophysiological mechanisms underlying cognitive decline in diabetes patients include hyperglycemia, insulin resistance and altered insulin signaling, neuroinflammation, cerebral microvascular injury, and buildup of cerebral amyloid and tau proteins.
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