Publications by authors named "Hanan A Althikrallah"
Article Synopsis
- Inflammation is a complex process that causes pain and involves the release of inflammatory mediators, prompting research into new treatments such as selenium-containing compounds (OSe).
- This study evaluated the anti-inflammatory properties of four specific selenium-based compounds (8, 9, 10, and 11) by measuring their effects on inflammatory markers COX-2, IL-1β, and IL-6, showing promising downregulation results.
- Molecular docking and dynamics simulations indicated strong binding affinities of these compounds to the COX-2 enzyme, suggesting they could be effective anti-inflammatory agents worth further development.
Background: Organoselenium (OSe) agents and Schiff bases have demonstrated immense potential in the pharmaceutical field due to their broad spectrum of medicinal activities.
Methods: We herein report the antitumor activities of bis diselenide-based Schiff bases (3a-3c) derived from bis(4-aminophenyl)diselenide 2 and organoselenide-based Schiff bases (5a-c) derived from p-(methylselanyl)phenyl amine (4). The antitumor activity was estimated against fifteen cancer cell lines.
Organoselenium (OSe) agents hold promise for preventing cancer due to their potential ability to fight cancer development and protect cells from oxidative damage. Herein, OSe-based maleanilic and succinanilic acids were tested to estimate their antitumor activities against fifteen cancer cell lines. Besides, their potential safety and selectivity were further investigated against two normal cell lines, namely, human skin fibroblasts (HSF) and olfactory ensheathing cell line (OEC) using the growth inhibition percentage (GI%) assay.
View Article and Find Full Text PDF