ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons.

Aim: Understanding the physiological role of ATP6V1A, a component of the cytosolic V domain of the proton pump vacuolar ATPase, in regulating neuronal development and function.

Methods: Modeling loss of function of Atp6v1a in primary murine hippocampal neurons and studying neuronal morphology and function by immunoimaging, electrophysiological recordings and electron microscopy.

Results: Atp6v1a depletion affects neurite elongation, stabilization, and function of excitatory synapses and prevents synaptic rearrangement upon induction of plasticity.