Publications by authors named "Hanae Konii"
Atheroprotective Effects of Tumor Necrosis Factor-Stimulated Gene-6.
JACC Basic Transl Sci
October 2016
Article Synopsis
- * The study showed that TSG-6 decreases inflammation and cell proliferation across human endothelial cells, macrophages, and smooth muscle cells, leading to less atherosclerotic development in mice.
- * Higher levels of TSG-6 were found in patients with coronary artery disease, indicating that TSG-6 might help stabilize atherosclerotic plaques and could be a new target for CAD treatment.
Aims: Omentin-1, a novel adipocytokine expressed in visceral fat tissue, is negatively correlated with obesity, insulin resistance, and stable coronary artery disease (CAD). However, there have been no previous reports regarding the effects of omentin-1 on atherogenesis.
Methods And Results: This study was performed to evaluate the atheroprotective effects of omentin-1 on human monocyte-derived macrophages, human aortic smooth muscle cells (HASMCs) in vitro, and aortic lesions in Apoe(-/-) mice in vivo.
Cardiotrophin 1 (CT-1), an interleukin-6 family cytokine, was recently shown to be expressed in the intima of early atherosclerotic lesions in the human carotid artery. CT-1 stimulates proatherogenic molecule expression in human vascular endothelial cells and monocyte migration. However, it has not been reported whether CT-1 accelerates atherosclerosis.
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