Publications by authors named "Hanaa N Alajami"
Article Synopsis
- 5-fluorouracil (5-FU) is an effective chemotherapy drug but can cause liver damage, necessitating research into protective agents like thymol, a compound found in thyme.
- Administration of thymol alongside 5-FU in rats showed it could reduce liver injury by boosting antioxidant levels and improving apoptotic markers.
- The study demonstrated, for the first time, thymol's ability to protect the liver by potentially modulating key signaling pathways involved in oxidative stress and apoptosis.
Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. Toll-4 receptors (TLR4) and NLPR3 inflammasome are pattern-recognition receptors responsible for activating inflammatory responses and are assigned to play a significant role with gasdermin (GSDMD) in acute kidney injuries.
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