A personalized, organ-based approach to the treatment of chronic steroid-refractory graft-versus-host disease.

Chronic graft-versus-host-disease (cGvHD) remains the leading cause of morbidity among transplant recipients. The efficacy of second-line treatments varies widely based on many factors, including wide differences in the organ overall response-rate response and in the current era where multiple agents are approved, and optimal sequencing of drugs based on organ ORR is unknown. We aimed to evaluate outcomes based on ORRs to the most common agents for the treatment of steroid-refractory/steroid-dependent cGvHD by conducting a systematic literature review.

Harnessing the Power of Blockchains and Machine Learning to End the COVID-19 Pandemic.

The last catastrophic pandemic the world has seen was the 1918 H1N1 influenza pandemic, considering that it happened 102 years ago, one can perhaps leverage the technologic advancements over the past century to combat the current pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19), which has already infected more than 16 million people globally and shut down the majority of the daily activities of life. The danger and challenge of infectious diseases such as COVID-19 lies in their highly contagious nature, spreading like wildfire with the potential to infect the majority of the world's population unless drastic measures are undertaken. In some countries, the social distancing and quarantine measures are either insufficient or ineffective as the number of cases is still on the rise.