Publications by authors named "Hanaa El Hachami"
Article Synopsis
- Previous studies indicated that phosphorylated tau (pTau) accumulation is linked to traumatic brain injury (TBI) rather than the frequency of seizures.
- The analysis of the Corsellis Epilepsy Collection revealed that CTE neuropathologic changes were present in 15.7% of cases, associated with factors like younger onset of epilepsy, TBI history, and memory impairment in a significant portion of those cases.
- The findings suggest a higher prevalence of CTE in epilepsy patients than in general populations, highlighting a potential increased risk of CTE associated with epilepsy syndromes.
Objectives: Dysfunctional connectivity and preexisting structural abnormalities of central autonomic network (CAN) regions have been shown on magnetic resonance imaging (MRI) in sudden unexpected death in epilepsy (SUDEP) and may be mechanistically relevant. In a previous postmortem study we reported increased microglia in CAN regions, including the superior temporal gyrus (STG) in SUDEP. In this current study we investigated mammalian target of rapamycin (mTOR) pathway activation and neuronal c-Fos activation in CAN regions in SUDEP compared to control groups.
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