Measuring respiratory and heart rate using a fiber optic interferometer: A pilot study in a neonate model.

Introduction: The study aim was to test the safety and efficacy of a pad with optic fibers developed for monitoring newborn respiratory rate (RR) and heart rate (HR).

Methods: Thirty New Zealand White rabbits were included, divided by weight into three groups. RR and HR were measured using two methods for each rabbit: ECG electrodes as the reference method and a newly developed pad with an experimental fiber optic system (EFOS) as the experimental method.

Risk factors for tumors or leukemia development in the first two years of life.

Objectives: The objective of this study was to determine the incidence of neoplastic diseases and associated risk factors in the early stages of life.

Methods: Data were retrospectively assessed in 730,000 live births between 2000 and 2019. The occurrence of tumors was monitored in the neonatal, infant (1-12 months), and toddler (13-24 months) periods.

Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants.

Background: The impact of the permissive hypotension approach in clinically well infants on regional cerebral oxygen saturation (rScO) and autoregulatory capacity (CAR) remains unknown.

Methods: Prospective cohort study of blinded rScO measurements within a randomized controlled trial of management of hypotension (HIP trial) in extremely preterm infants. rScO, mean arterial blood pressure, duration of cerebral hypoxia, and transfer function (TF) gain inversely proportional to CAR, were compared between hypotensive infants randomized to receive dopamine or placebo and between hypotensive and non-hypotensive infants, and related to early intraventricular hemorrhage or death.

Hypotension in Preterm Infants (HIP) randomised trial.

Objective: To determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.

Design: Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.

A rare form of ankyloblepharon filiforme adnatum associated with the Hay-Wells syndrome and a c.1709T>C mutation on the TP63 gene.

Introduction: Ankyloblepharon filiforme adnatum associated with Hay-Wells syndrome is a rare congenital disease caused by mutations in TP63 gene on the 3q27 chromosome. Here, we report a case of a new-born suffering from this syndrome in whom we detected a mutation c.1709T>C not previously included in the Ensemble database.

Changes in middle cerebral artery velocimetry of fetuses diagnosed postnatally with mild or moderate hemolytic disease.

Objectives: To determine the longitudinal trends of middle cerebral artery peak systolic velocity (MCA PSV) in fetuses with mild or moderate hemolytic disease according to the need for postnatal therapy.

Design: Prospective cohort study.

Setting: University referral center.