Antidepressant-Like Activity of Solvent Fractions of the Root Bark of Linn. (Apocynaceae) in Rodents Involves Multiple Signaling Pathways.

Background: The root bark of Linn. (Apocynaceae) is claimed to be used for the management of depression in Ethiopian folkloric medicine, and the crude extract has been reported to possess antidepressant-like activity in rodents.

Objective: This study aimed to evaluate the antidepressant-like effect of different fractions of the root bark in rodents and the possible underlying mechanisms in rats.