Engineered luciferase-luciferin pairs have expanded the number of cellular targets that can be visualized in tandem. While light production relies on selective processing of synthetic luciferins by mutant luciferases, little is known about the origin of selectivity. The development of new and improved pairs requires a better understanding of the structure-function relationship of bioluminescent probes.
View Article and Find Full Text PDFAims: To understand GP trainees' experience of out-of-hours (OOH) training in England; whether it is achieving educational aims, and to highlight potential improvements. Additionally to explore factors that influence the decision to work in OOH care.
Methods: An online survey was sent to 1091 GP trainees in England.
Objective: We sought to explore parents and carers' experiences of searching for information about childhood eczema on the internet.
Design: A qualitative interview study was carried out among carers of children aged 5 years or less with a recorded diagnosis of eczema. The main focus of the study was to explore carers' beliefs and understandings around eczema and its treatment.
Cochrane Database Syst Rev
August 2014
Background: Tinea infections are fungal infections of the skin caused by dermatophytes. It is estimated that 10% to 20% of the world population is affected by fungal skin infections. Sites of infection vary according to geographical location, the organism involved, and environmental and cultural differences.
View Article and Find Full Text PDFBackground: Childhood eczema, or childhood atopic dermatitis, causes significant distress to children and their families through sleep disturbance and itch. The main cause of treatment failure is nonuse of prescribed treatments.
Objective: The objective of this study was to develop and test a Web-based intervention to support families of children with eczema, and to explore whether support from a health care professional (HCP) is necessary to engage participants with the intervention.
Aim: To explore parents and carers' experiences of barriers and facilitators to treatment adherence in childhood eczema
Background: Childhood eczema is common and causes significant impact on quality of life for children and their families, particularly due to sleep disturbance and itch. Non-adherence to application of topical treatments is the main cause of treatment failure.
Design: Qualitative interview study.
Background: Childhood eczema causes significant impact on quality of life for some families, yet non-concordance with treatment is common.
Aim: To explore parents' and carers' views of childhood eczema and its treatment.
Design And Setting: Qualitative interview study in primary care in the south of England.
Background: Since 2006 the Quality Outcomes Framework (QOF) has rewarded GPs for carrying out standardised assessments of the severity of symptoms of depression in newly diagnosed patients.
Aim: To gain understanding of GPs' opinions and perceived impact on practice of the routine introduction of standardised questionnaire measures of severity of depression through the UK general practice contract QOF.
Design Of Study: Semi-structured qualitative interview study, with purposive sampling and constant comparative analysis.
Objective: To gain understanding of general practitioners' and patients' opinions of the routine introduction of standardised measures of severity of depression through the UK general practice quality and outcomes framework.
Design: Semistructured qualitative interview study, with purposive sampling and constant comparative analysis.
Participants: 34 general practitioners and 24 patients.