Short- and long-term administration of buprenorphine improved gene expression of PX and GABAA receptors in the hippocampus of methamphetamine rats.

PX receptors modulate synaptic transmission and communication among neurons in the CNS. An increased level of neuronal PX is associated with altered memory in the hippocampal region. Additionally, some evidence suggests that PX receptors downregulate the GABA receptors.