Donor-acceptor engineering of a triplet-exciton-optimized MOF photocatalyst for efficient singlet oxygen-mediated oxidation.

The exploration of photocatalysts (PCs) for efficient singlet oxygen (O)-based photocatalytic oxidation is critical and challenging. Herein, a new series of donor-acceptor metal-organic frameworks (D-A MOFs) are constructed through the engineering of the D-A system, and investigated as PCs for the O oxidation reaction. By regulating the intersystem crossing and reversed intersystem crossing features of the D-A system, D-A MOFs could reveal highly tunable triplet-exciton generation.

A dose-response meta-analysis of physical activity and the risk of alzheimer's disease in prospective studies.

Background: Alzheimer's disease (AD) has become an increasing global health challenge, particularly with the accelerated aging of the population. Therefore, preventive research targeting AD has become especially important. In recent years, physical activity (PA), as a potential non-pharmacological intervention, has garnered increasing attention from researchers.

Global, regional and national burden and trends of larynx cancer among adults aged 55 and older from 1990 to 2021: results from the global burden of disease study 2021.

Background: Laryngeal cancer (LC), as a common head and neck tumor, significantly impacts the quality of life. Utilizing data from the 2021 Global Burden of Disease (GBD) study, we sought to delve deeply into the global LC burden experienced by individuals aged 55 and older from 1990 to 2021 at the global, regional, and national levels. This research encompassed three key indicators: incidence rate, mortality, and disability-adjusted life years (DALYs).

Correlation of multiple peripheral blood parameters with metastasis and invasion of papillary thyroid cancer: a retrospective cohort study.

Objective: Papillary thyroid cancer (PTC) progression is characterized by lymph node metastasis and thyroid capsular invasion. This study aimed to identify high-risk PTC populations for these events based on peripheral blood test parameters and to determine the associated factors.

Methods: This retrospective study analyzed data from 4557 PTC patients.

SEPT14 complexes maintain sperm morphogenesis and function.

Mutations in the septin (SEPT) family lead to male infertility. Septin 14 (SEPT14) is abundantly expressed in the testis, and its expression is significantly reduced in individuals with teratozoospermia, suggesting that SEPT14 may play a role in spermatogenesis. Here, we demonstrated that Sept14 is expressed mainly at the acroplaxome, manchette, neck, and annulus during spermiogenesis.

Relative Fat Mass, A Better Predictor of Erectile Dysfunction: Insights From the NHANES 2001-2004.

Obesity is a significant factor contributing to erectile dysfunction (ED). Early detection of ED generally results in improved treatment outcomes. Our study aims to elucidate the association between relative fat mass (RFM) and ED by analyzing data from the National Health and Nutrition Inspection Survey (NHANES) spanning 2001 to 2004.

Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study.

Many observational epidemiological studies have reported an association between matrix metalloproteinases (MMPs) and urologic cancers. However, the causal relationship between these two phenotypes remains uncertain. This study aims to examine the bidirectional causal relationship between serum MMPs and three urologic cancers: kidney, prostate, and bladder cancer.

Decreased Hysteresis Benefited from Enhanced Lattice Oxygen and Promoted Band Alignment with Electron Transport Layer Modification in Perovskite Solar Cells.

SnO electron transport layer (ETL) morphology plays a vital role in carrier transportation and the properties of perovskite solar cells (PSCs). However, the uneven and pore surface would inevitably lead to high interface defects, high hysteresis, and poor performance. In this work, we use a molecular modifier 4-guanidinobenzoic acid methanesulfonate (GAMSA) to build a molecular bridge on the buried interface of SnO/perovskite.

Exploration of enalapril-lacidipine co-amorphous system with superior dissolution, in vivo absorption and physical stability via incorporated into mesoporous silica.

In the present study, enalapril (ENP) was taking as a potential co-former to fabricate co-amorphous system with lacidipine (LCDP). The ENP/LCDP co-amorphous system was firstly prepared with or without mesoporous SiO and characterized by DSC, XRD and SEM technologies. The potential molecular interactions were evaluated by FTIR spectrums.

Buyang Huanwu decoction promotes gray and white matter remyelination by inhibiting Notch signaling activation in the astrocyte and microglia after ischemic stroke.

Ethnopharmacological Relevance: Ischemic stroke causes damages to both gray and white matter, resulting in long-term motor impairments. Myelin repair is a promising strategy for poststroke motor rehabilitation. Buyang Huanwu Decoction (BHD) is a classical traditional Chinese medicine formula for managing the sequelae of ischemic stroke.

UTR-Insight: integrating deep learning for efficient 5' UTR discovery and design.

The 5' UTR is critical for mRNA stability and translation efficiency in therapeutics. We developed UTR-Insight, a model integrating a pretrained language model with a CNN-Transformer architecture, explaining 89.1% of the mean ribosome load (MRL) variation in random 5' UTRs and 82.

Advances in adhesion of microneedles for bioengineering.

Microneedles have provided promising platforms in various fields thanks to their safety, painlessness, minimal invasiveness and ease of operation. The excellent adhesion of microneedles is the key characteristic to achieve long-term and comfortable treatment. However, a complex environment, such as the roughness of skin, various bodily fluids , and the movement of the body, presents great challenges to the adhesion characteristics of microneedles.

Molecular Epidemiology of Type F Among Diarrheal Patients and Virulence-Resistance Dynamics - 11 Provinces, China, 2024.

Introduction: Type F () represents a significant pathogen in human gastrointestinal diseases, primarily through its gene encoding enterotoxin (CPE). This investigation examined the prevalence, antimicrobial resistance patterns, and genetic characteristics of Type F within the Chinese population.

Methods: The study analyzed 2,068 stool samples collected from 11 provincial hospitals in 2024.

An ultrasensitive ECL immunosensor with a dual signal amplification strategy using AuNPs@GO@SmMoSe and Gd(MoO) for estriol detection.

Background: Estriol (E3) is a common estrogen responsible for regulating the female reproductive system, but excessive amount can pose health risks to humans and wild life. Therefore, sensitive and accurate detection of estriol level is crucial. A novel competitive ECL immunosensor based on a dual signal amplification strategy of AuNPs@GO@SmMoSe and Gd(MoO) was fabricated for ultrasensitive detection of estriol.

Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis.

Background: To date, several studies have demonstrated that erroneous labeling of Penicillin allergy (PAL) can significantly impact treatment options and result in adverse clinical outcomes, while other studies have reported no negative effects. Therefore, to systematically evaluate these effects and investigate the association between adverse clinical outcomes and the Penicillin label, we conducted this meta-analysis.

Method: Searches were conducted in the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to 13 July 2024.

Designing Chiral Organometallic Nanosheets with Room-Temperature Multiferroicity and Topological Nodes.

Two-dimensional (2D) room-temperature chiral multiferroic and magnetic topological materials are essential for constructing functional spintronic devices, yet their number is extremely limited. Here, by using the chiral and polar HPP (HPP = 4-(3-hydroxypyridin-4-yl)pyridin-3-ol) as an organic linker and transition metals (TM = Cr, Mo, W) as nodes, we predict a class of 2D TM(HPP) organometallic nanosheets that incorporate homochirality, room-temperature magnetism, ferroelectricity, and topological nodes. The homochirality is introduced by chiral HPP linkers, and the change in structural chirality induces a topological phase transition of Weyl phonons.

Regulation of TADF by Internal and External Heavy Atom Effect in D-A MOF for Heterocrystal based Temperature-Compensated Photonic Device.

The application of temperature-compensated photonic device is hampered by poor accuracy and overly simplistic functions of propagation in photonic integrated circuits (PICs) field. Herein, we report a new library of donor-acceptor metal-organic framework (D-A MOF) with thermally activated delayed fluorescence (TADF) and the fabricating of temperature-compensated photonic device by virtue of the unique temperature response character of TADF emitters. Highly tunable through-space charge transfer (TSCT) of TADF was realized within the D-A MOFs through a novel strategy that synergistically combines the internal heavy atom effect (HAE) with an external HAE, induced by the incorporation of heavy atoms into different components, achieving the regulable photophysical indicators including adjustable PL wavelength (534 to 592 nm) and surging quantum yield (5.

Correspondence between Euler charges and nodal-line topology in Euler semimetals.

Real multi-bandgap systems have non-abelian topological charges, with Euler semimetals being a prominent example characterized by real triple degeneracies (RTDs) in momentum space. These RTDs serve as "Weyl points" for real topological phases. Despite theoretical interest, experimental observations of RTDs have been lacking, and studies mainly focus on individual RTDs.

MHTAPred-SS: A Highly Targeted Autoencoder-Driven Deep Multi-Task Learning Framework for Accurate Protein Secondary Structure Prediction.

Accurate protein secondary structure prediction (PSSP) plays a crucial role in biopharmaceutics and disease diagnosis. Current prediction methods are mainly based on multiple sequence alignment (MSA) encoding and collaborative operations of diverse networks. However, existing encoding approaches lead to poor feature space utilization, and encoding quality decreases with fewer homologous proteins.

Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer-A retrospective study.

Purpose: The purpose of this study was to determine the efficacy and safety of low-dose radiotherapy (LDR) for postoperative local chest wall recurrence of breast cancer.

Methods: The records of 52 patients with postoperative local chest wall recurrent breast cancer treated at our cancer center from January 2019 to December 2022. The t-test was used to compare the means of the LDR group and non LDR group.

Downregulation of the PI3K/AKT/mTOR/MMP-13 pathway for promoting interface healing via lubricating microspheres.

Interface friction impedes tissue healing and stimulates interface cells to produce matrix metalloproteinases (MMPs); however, the precise mechanisms underlying matrix degradation, and the formation of fibrous scars remain unclear. This research involved the development of interface lubricating microspheres that inhibit the PI3K/AKT/mTOR signaling pathway in tenocytes. This inhibition significantly decreased MMP-13 expression and increased COL-1 production, thereby facilitating interface repair and regeneration.

Donor-Acceptor Functionalized Water-Soluble Metal-Organic Cages Showing an Excellent Synergistic Photothermal-Chemotherapy Effect.

Water-soluble metal-organic cages (WSMOCs) show high potential as antitumor agents, while the targeted functionalization of WSMOCs toward enhanced antitumor performances is a challenging task. Herein, WSMOCs were functionalized with donor-acceptor (D-A) systems for synergistic photothermal-chemotherapy. Octahedral [ML] cages based on a 2,4,6-tri(2-pyridine-4-yl)-1,3,5-triazine (TPT) acceptor and M(bpy) (M = Pd for , Pt for ) nodes were functionalized with tetrathiafulvalene (TTF) to form and .

Application of Fourier transform infrared spectroscopy to exhaled breath analysis for detecting helicobacter pylori infection.

Helicobacter pylori (H. pylori) is one of the most globally prevalent bacteria, closely associated with gastrointestinal diseases such as gastric ulcers and chronic gastritis. Current clinical methods primarily involve Carbon-13 and Carbon-14 urea breath test, both carrying potential safety risks.