Publications by authors named "Han-zhu Qian"
Background: Observational studies suggest that voluntary medical male circumcision (VMMC) may lower HIV risk among men who have sex with men (MSM). A randomized controlled trial (RCT) is needed to confirm this.
Objective: To assess the efficacy of VMMC in preventing incident HIV infection among MSM.
Article Synopsis
- A systematic review was conducted to analyze the global transmission rates of asymptomatic SARS-CoV-2 infections, following PRISMA guidelines and utilizing data from four major databases until January 2021.
- Out of 4923 records, 15 studies involving 3917 close contacts of asymptomatic cases were included, revealing a pooled transmission rate of 1.79% for asymptomatic individuals, which is significantly lower than rates for presymptomatic (5.02%) and symptomatic infections (5.27%).
- The study found that transmission rates were higher in household settings (4.22%) compared to non-household settings (1.03%), and asymptomatic transmission rates were lower in China (1.82%) than in other
Article Synopsis
- The study examines the relationship between HIV status and health outcomes in heart failure (HF) patients, aiming to clarify whether HIV impacts readmissions and mortality in these individuals.
- Analysis included 7 cohort studies with over 58,000 HF patients, revealing that those with HIV faced a 20% higher risk of all-cause deaths and significantly increased rates of HF-related and overall readmissions.
- This research underscores the need for better management strategies for heart failure patients who are also living with HIV, given the independent risks associated with the virus.
Black men who have sex with men (MSM) continue to have the highest incidence of new human immunodeficiency virus (HIV) diagnoses in the United States but are least likely to be engaged in care or to be virally suppressed. Many Black MSM face multiple stigmas, but some have found refuge in the House Ball Community (HBC)-a national network of Black lesbian, gay, bisexual, and transgender kinship commitments that provide care-giving, affirmation, and survival skills-building for its members. We propose to modify a skills-building and HIV prevention best-evidence, group-level intervention for HIV- negative Black MSM (Many Men Many Voices) into a family-based intervention to focus on asset-building for both HIV-negative and HIV-positive Black MSM within HBC families.
View Article and Find Full Text PDFIntroduction: Delayed antiretroviral therapy (ART) initiation is associated with poor HIV outcomes and a higher likelihood of HIV transmission.
Methods: This cross-sectional study assessed the proportion of delayed ART initiation which was defined as initiating ART after 30 days of HIV diagnosis, and evaluated the pathways influencing ART initiation among adult PLWH in Changsha, China who were diagnosed between 2014 and 2022.
Results: Of 518 participants, 37.
Background: A continuing nationwide vaccination campaign began in the Dominican Republic on February 16, 2021 to prevent severe consequences of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Estimates of vaccine effectiveness under real-world conditions are needed to support policy decision making and inform further vaccine selection.
Methods: We conducted a test-negative case-control study to assess the real-world effectiveness of nationwide coronavirus disease 2019 (COVID-19) vaccination program using an inactivated vaccine (CoronaVac) on preventing symptomatic SARS-CoV-2 infections and hospitalizations from August to November 2021 in the Dominican Republic.
Article Synopsis
- * The analysis included 11 cohort studies and 11 case reports, revealing a reinfection incidence rate of 0.70 per 10,000 person-days, which is significantly lower than the incidence rate for new infections.
- * The findings suggest that while prior infection does lower the risk of reinfection, ongoing monitoring is essential as new variants of the virus, like Omicron, could alter this risk.
Introduction: Diagnosis and treatment represent distressing experiences for the families of children with cancer. Psychosocial challenges are faced by these families in China because of limited health services and resources for psychosocial oncology care. Effective interventions tailored to the knowledge level and cultural values of this population are needed.
View Article and Find Full Text PDFPeople ageing with HIV face crucial challenges that can compromise their long-term health, one of which is stigma. HIV-related stigma can interact with other coexistent inequities to create a unique oppression system that results in traumatic experiences. This intersectionality of stigmas represents a new inequality that is greater than the sum of the original component inequalities.
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- - HIV self-testing (HIVST) is found to increase testing frequency among men who have sex with men (MSM), but its effect on sexual risk behaviors remains uncertain.
- - A study in Hunan Province, China, involved 230 HIV-negative MSM, who were divided into two groups: one received standard HIV testing, while the other also received free HIV self-test kits for a year.
- - Results showed no significant changes in consistent condom use or the number of sexual partners between the two groups, indicating that providing free HIVST kits does not promote risky sexual behaviors and should be integrated into HIV prevention strategies for sexual minority men.
Article Synopsis
- Non-AIDS-defining cancers (NADCs) are becoming more prevalent among people living with HIV (PLHIV) due to better access to antiretroviral therapy (HAART), leading to increased morbidity and mortality.
- A systematic review and meta-analysis of 92 studies revealed that PLHIV have a higher incidence and mortality rate for many NADCs, particularly those associated with infections like HPV.
- The findings indicate that the risk of developing these cancers is even greater in PLHIV with advanced immunodeficiency and varies based on the HIV transmission route and HAART use.
Article Synopsis
- People living with HIV (PLWH) are at a higher risk of death if infected with COVID-19, making them a priority group for vaccination.
- An online survey conducted in early 2021 with 2,740 PLWH across eight cities in China found that only 6.2% had received the COVID-19 vaccine.
- Factors influencing vaccination uptake included access to vaccination appointments, concerns about side effects, and receiving support from community organizations; additionally, misinformation or vaccine shortages hindered vaccination rates.
Background: Lockdown measures for controlling the COVID-19 epidemic were enforced in China between January and May 2020. Previous studies showed a decrease in HIV high- Risk Behaviors (HRBs) and updated testing during the lockdown, but little is known about these behaviors during the post-lockdown period.
Objective: We conducted quantitative and qualitative assessments of HIV-related behaviors among MSM during the lockdown and post-lockdown periods in Changsha, south-central China.
Article Synopsis
- The study focuses on the prevalence of human papillomavirus (HPV) in oropharyngeal cancer, finding that it is the site with the highest HPV infection in head and neck cancers.
- Researchers updated estimates of oropharyngeal, tonsillar, and base of tongue cancers linked to HPV globally, highlighting that in 2012, around 42,000 and 20,000 new cases were attributable to HPV, with higher rates in developed countries.
- The analysis suggests that a significant percentage of HPV-positive oropharyngeal cancers could be prevented with existing HPV vaccines, emphasizing the need for HPV vaccination, particularly in males and high-prevalence regions.
Background: Antiretroviral therapy (ART) has reduced mortality among people living with HIV (PLWH) in China, but co-infections of hepatitis B virus (HBV) and hepatitis C virus (HCV) may individually or jointly reduce the effect of ART. This study aimed to evaluate the impacts of HBV/HCV coinfections on treatment drop-out and mortality among PLWH on ART.
Methods: A retrospective cohort study analysis of 58 239 people living with HIV (PLWH) who initiated antiretroviral therapy (ART) during 2010-2018 was conducted in Guangxi Province, China.
Background: Men with have sex with men (MSM) in Africa face high levels of stigma due to elevated HIV exposure (actual or perceived), same-sex practices, and gender non-conformity. These stigmas are documented barriers to HIV prevention and treatment. Most stigma-reduction interventions have focused on single-level targets (e.
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- HIV infection increases the risk of severe COVID-19, prompting the need for vaccination among people living with HIV/AIDS (PLWHA).
- A study conducted in China surveyed 2,570 PLWHA about their willingness to receive the COVID-19 vaccine, revealing that 57.2% showed willingness.
- Key factors influencing vaccine willingness included positive attitudes towards vaccination, perceived social support, and awareness of vaccination benefits.
Background: Assisted partner notification (PN) is an effective approach for increasing HIV testing among heterosexual partners. There is sparse evidence on its effect among sexual partners of men who have sex with men (MSM).
Methods: A randomized controlled trial was conducted to compare the effect of assisted PN and passive PN interventions on uptake of HIV testing among male and female sexual partners of newly HIV-diagnosed MSM.
Human papillomavirus (HPV) infection and related diseases are common among men who have sex with men (MSM). The most effective prevention is HPV vaccination. In China, however, men are not included in the HPV vaccination plan.
View Article and Find Full Text PDFBackground: Medical male circumcision (MMC) reduces HIV infection among heterosexual men. There are concerns MMC might prompt higher-risk sexual behaviours because of lower self-perceived risk of HIV infection. We reviewed the published literature to examine associations between MMC and both condom use and number of sex partners among heterosexual men.
View Article and Find Full Text PDFRecent evidence shows that circumcision is associated with lower HIV prevalence among MSM. We assessed the acceptability of circumcision for preventing HIV and that of Shang Ring circumcision (SRC) among men who have sex with men (MSM) in China. 538 adult MSM were recruited from six cities in China between January and March 2019.
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- A meta-analysis was conducted on HIV testing rates among couples of individuals diagnosed with HIV in China, using data from six electronic databases and conference abstracts.
- The analysis revealed that 65% of couples underwent HIV testing, with an overall HIV prevalence rate of 28% among those tested.
- Specific groups showed varied testing rates, with 76% of pregnant women testing and only 49% of men who have sex with men (MSM), indicating a need for improved testing strategies for MSM couples.
Objective: To synthesize evidence on the association between human immunodeficiency virus (HIV) infection and cognitive impairment in older adults.
Design: Meta-analysis.
Participants: Adults aged 50 years or older.