Generative learning facilitated discovery of high-entropy ceramic dielectrics for capacitive energy storage.

Dielectric capacitors offer great potential for advanced electronics due to their high power densities, but their energy density still needs to be further improved. High-entropy strategy has emerged as an effective method for improving energy storage performance, however, discovering new high-entropy systems within a high-dimensional composition space is a daunting challenge for traditional trial-and-error experiments. Here, based on phase-field simulations and limited experimental data, we propose a generative learning approach to accelerate the discovery of high-entropy dielectrics in a practically infinite exploration space of over 10 combinations.

Programming Polarity Heterogeneity of Energy Storage Dielectrics by Bidirectional Intelligent Design.

Dielectric capacitors, characterized by ultra-high power densities, are considered as fundamental energy storage components in electronic and electrical systems. However, synergistically improving energy densities and efficiencies remains a daunting challenge. Understanding the role of polarity heterogeneity at the nanoscale in determining polarization response is crucial to the domain engineering of high-performance dielectrics.

Texture Engineering Modulating Electromechanical Breakdown in Multilayer Ceramic Capacitors.

Understanding the electromechanical breakdown mechanisms of polycrystalline ceramics is critical to texture engineering for high-energy-density dielectric ceramics. Here, an electromechanical breakdown model is developed to fundamentally understand the electrostrictive effect on the breakdown behavior of textured ceramics. Taking the Na Bi TiO -Sr Bi TiO ceramic as an example, it is found that the breakdown process significantly depends on the local electric/strain energy distributions in polycrystalline ceramics, and reasonable texture design could greatly alleviate electromechanical breakdown.

Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway.

Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements significantly restored the cognitive deficits in ICV-STZ rat model including shorter escape latency, more crossing times and increased time spent in the target quadrant.

[Effects of tempol on white matter lesions and cognitive impairment in a rat model of chronic cerebral hypoperfusion].

Objective: To assess the neuroprotective effect of Tempol, an antioxidant acting as a superoxide dismutase mimic, on white matter lesions and cognitive impairment in rats with chronic cerebral hypoperfusion.

Methods: Chronic cerebral ischemia was induced by permanent occlusion of bilateral common carotid arteries (2-VO) in male Wistar rats. The animals were divided into sham operation, saline-treated, Tempol (8 mg/kg) and Tempol (30 mg/kg) groups (n = 15 each).

Dielectric properties of lead-free BZT-KNN perovskite ceramics for energy storage.

Lead-free (1-x)Ba(Zr₀.₁₅Ti₀.₈₅)O₃-x(K₀.

Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus.

Abstract Deposition of ubiquitinated protein aggregates is a hallmark of neurodegeneration in both acute neural injuries, such as stroke, and chronic conditions, such as Parkinson's disease, but the underlying mechanisms are poorly understood. In the present study, we examined the role of Zn2+ in ischemia-induced impairment of the ubiquitin-proteasome system in the CA1 region of rat hippocampus after transient global ischemia. We found that scavenging endogenous Zn2+ reduced ischemia-induced ubiquitin conjugation and free ubiquitin depletion.

[IR study of the hardening and maturation of glass ionomer cement].

The set reaction of glass ionomer cement has been investigated by means of IR spectra. It has been found that the band intensity around 1413 cm(-1) due to the vibration of polyacrylate salt increased with aging, and the shoulder band at 950 cm(-1) due to the stretching vibration of Si-OH still appeared during the periods studied. The results are consistent with that of mechanical determination of compressive strength, which suggested that the crosslink density increase resulting from the slow diffusion of Ca2+ and Al3+ is responsible for compressive strength increasing with aging, and forming and maturing of interface layer comprising of silica gel also have a significant effect on the properties of glass ionomer cements.

Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment.

Chronic cerebral hypoperfusion causes cognitive impairment, but the underlying molecular mechanism is not well understood. We used permanent occlusion of bilateral common carotid arteries (2-VO) to induce chronic cerebral hypoperfusion in male Wistar rats. Cognitive impairment and the expression patterns of MAP-2, GAP-43, and synaptophysin were examined.