Publications by authors named "Han-wu Ma"

Four enterovirus D68 (EV-D68) strains from four children with influenza-like illness were identified in Shenzhen, southern China, in late 2015. Here, we announce the availability of these viral genomes in GenBank. The genomic sequences of these EV-D68 strains showed the closest phylogenetic relationship to strains from northern China.

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Objective: This study aimed to describe the trends of motorization and mortality rates from road traffic accidents and examine their associations in a rapidly urbanizing city in China, Shenzhen.

Methods: Using data from the Shenzhen Deaths Registry between 1994 and 2013, we calculated the annual mortality rates of road traffic accidents, in addition to the age- and sex-specific mortality rates and their annual percentage changes (APCs) for the period of 2000-2013. We also examined the associations between mortality rate of road traffic accidents and traffic growth with Spearman's rank correlation analysis and a log-linear model derived from Smeed's law.

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Article Synopsis
  • * Attack rates were 15.9% among elderly (31/195) and 23.2% among staff (19/82), with 13 asymptomatic cases in the staff contributing to the spread.
  • * Gene sequencing confirmed the virus was transmitted person-to-person, starting from a self-cared elder who got infected outside the facility and facilitating cross-transmission through close contact among residents and staff.
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Background: Influenza has been associated with heavy burden of mortality and morbidity in subtropical regions. However, timely forecast of influenza epidemic in these regions has been hindered by unclear seasonality of influenza viruses. In this study, we developed a forecasting model by integrating multiple sentinel surveillance data to predict influenza epidemics in a subtropical city Shenzhen, China.

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Objective: To understand the infection status and epidemiological features of HBV in permanent residents of Shenzhen city.

Methods: A multi-stage stratified random sampling method was performed for questionnaire survey to permanently-registered residents of 1-59 years old in Luohu and Baoan district of Shenzhen in 2010, and blood samples of the subjects were collected. Hepatitis B virus-related surface antigen (HBsAg) and hepatitis B virus surface antibody (anti-HBs) were detected with ELISA.

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Article Synopsis
  • Recent outbreaks of hand, foot, and mouth disease (HFMD) in Shenzhen, China, raised concerns about human enterovirus (HEV) serotypes, particularly the prevalence of non-HEV71 and non-cocksackievirus A16 strains.
  • A study analyzing 2,411 clinical stool specimens from 2008 to 2012 found that 74.8% were HEV-positive, with HEV71 being the most common (60.0%), while CV-A6 emerged as a significant player by 2012.
  • Phylogenetic analysis indicated low variation in HEV71 and CV-A16 strains in China, while CV-A6 and CV-A10 strains showed geographic differences, suggesting a
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Objective: To study the infection status and the molecular characteristics of Vibrio parahaemolyticus isolated from diarrheal patients in Shenzhen, in 2007 to 2008 and to provide evidence for the prevention and control of diarrheal diseases caused by Vibrio parahaemolyticus.

Methods: More than 80 fecal specimens from four sentinel surveillance hospitals were collected and cultured each month. A total of 361 isolates of Vibrio parahaemolyticus were sero-typed and examined by real-time PCR for the presence of two major virulence genes, tdh and trh.

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Objective: Based on analyzing the characteristics of a case with human avian influenza and the effects of field epidemiological study.

Methods: An emergency-response-system was started up to follow the probable human Highly Pathogenic Avian Influenza case initially detected by the "Undefined Pneumonia Surveillance System of Shenzhen". Public health professionals administered several epidemiologic investigations and giving all the contacts of the patient with a 7-day-long medical observation for temporally related influenza-like illness.

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