Treatment response assessment to chemotherapy with bevacizumab for colorectal liver metastasis by contrast-enhanced ultrasound.

Background: Though contrast-enhanced ultrasound (CEUS) perfusion parameters have been approved to be potential indicators for response to chemotherapy in solid tumors, their ability in assessment of colorectal liver metastasis (CRLM) to chemotherapy with bevacizumab (Bev) has rarely been investigated.

Methods: From March 2021 to May 2022, 115 consecutive CRLM patients with CEUS pre- and post-2 months' chemotherapy with Bev were prospectively enrolled. One target lesion per patient underwent CEUS quantitative analysis with SonoLiver software.

Oceanic non-Kolmogorov optical turbulence and spherical wave propagation.

Light propagation in turbulent media is conventionally studied with the help of the spatio-temporal power spectra of the refractive index fluctuations. In particular, for natural water turbulence several models for the spatial power spectra have been developed based on the classic, Kolmogorov postulates. However, as currently widely accepted, non-Kolmogorov turbulent regime is also common in the stratified flow fields, as suggested by recent developments in atmospheric optics.

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.

Objectives: To investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms.

Methods: Orthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI-MS. A potassium oxonate (PO) induced hyperuricemic mouse model was used to evaluate antihyperuricemia and nephroprotective effects of O.

Carthamin yellow inhibits matrix degradation and inflammation induced by LPS in the intervertebral disc via suppression of MAPK pathway activation.

Carthamin yellow (CY), which is a flavonoid compound isolated from safflower, has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. CY is a herb used in Chinese traditional medicines. Intervertebral disc degeneration (IDD) is a common spinal disorder and degeneration of nucleus pulposus (NP) cells and inflammation are significant parts of the pathological cascade.

[Physico-chemical Characteristics of Individual Aerosol Particles in Marine Atmosphere on South Hemisphere].

During the 29 Chinese National Antarctic Research Expedition (CHIANRE), individual particle samples were collected from South China to Antarctic during November 2012 to April 2013. A transmission electron microscopy with energy-dispersive X-ray spectrometry (TEM-EDS) was employed to analyze the morphology, mixing state, composition, and relative abundances of individual aerosol particles. Atmospheric particles were classified into four types:sea salt, mineral, S-rich and C-rich.

Neurokinin-1 Receptor-Immunopositive Neurons in the Medullary Dorsal Horn Provide Collateral Axons to both the Thalamus and Parabrachial Nucleus in Rats.

It has been suggested that the trigemino-thalamic and trigemino-parabrachial projection neurons in the medullary dorsal horn (MDH) are highly implicated in the sensory-discriminative and emotional/affective aspects of orofacial pain, respectively. In previous studies, some neurons were reported to send projections to both the thalamus and parabrachial nucleus by way of collaterals in the MDH. However, little is known about the chemoarchitecture of this group of neurons.

Endoscopic submucosal dissection versus transanal local excision for rectal carcinoid: a comparative study.

Aim: The aim of this study is to compare the short-term clinical outcomes between endoscopic submucosal dissection and transanal local excision for rectal carcinoid tumors.

Methods: Between 2007 and 2012, 31 patients with rectal carcinoid underwent endoscopic submucosal dissection at our hospital. They were compared with a matched cohort of 23 patients who underwent transanal local excision for rectal carcinoid between 2007 and 2012.

Lever reduction using polyaxial screw and rod fixation system for the treatment of degenerative lumbar spondylolisthesis with spinal stenosis: technique and clinical outcome.

Background: The management for degenerative lumbar spondylolisthesis with spinal stenosis remains controversial. Reduction of lumbar spondylolisthesis has been performed via numerous techniques. Most of them need extra reduction assembly.

[Molecular classification of colorectal carcinoma based on integration of gene expression profile and copy number variation].

Objective: To classify colorectal carcinoma (CRC) by TNM staging integrated with the gene expression profile and copy number variation (CNV).

Methods: Profile data of gene expression and CNV of CRC were downloaded from public database and processed with batch bias adjustment, quartile normalization, missing value estimation and feature filtration. The processed profiles of mRNA and CNV were introduced into the codes of Bayesian consensus clustering (BCC) method and were used to calculate the subclasses of CRC.

[Emergence application of colonoscopic placement of self-expandable metal stent without fluoroscopic monitoring].

Objective: To evaluate the efficacy and safety of colonoscopy-guided placement of self-expandable metallic stent without fluoroscopic monitoring in the emergence management for acute malignant colorectal obstruction.

Methods: Clinical data of 42 patients (24 males and 18 females with a mean age of 64.3 years) undergoing colonoscopy-guided placement of self-expandable metallic stents without fluoroscopic monitoring for acute malignant colorectal obstruction between January 2010 and June 2012 were reviewed retrospectively.

[Colonoscopic restoration for sigmoid vovulus in the elderly].

Objective: To investigate the emergency therapeutic strategy for sigmoid vovulus in the elderly.

Methods: Clinical data of 14 elderly patients with sigmoid vovulus were analyzed retrospectively.

Results: The mean age was(79.

[Surgical treatment of recurrent colorectal carcinoma in the elderly].

Objective: To evaluate the safety and efficacy of surgical treatment for recurrent colorectal carcinoma in the elderly.

Methods: The clinical and follow up data of 24 elderly patients with recurrent colorectal carcinoma who were treated between January 2000 and June 2009 at the Changhai hospital of the Second Military Medical University were analyzed retrospectively.

Results: Among the 24 patients there were 14 men and 10 women.

[Analysis on misdiagnosis of 271 patients with rectal cancer].

Objective: To investigate the common reasons for the misdiagnosis of rectal cancer.

Methods: A retrospective study was performed in 568 cases of rectal cancer in the Changhai Hospital from January 2007 to December 2008. Age at diagnosis, gender distribution, symptom, delay in diagnosis, TNM stage, and grade of differentiation were recorded and analyzed.

Posterior unilateral pedicle subtraction osteotomy of hemivertebra for correction of the adolescent congenital spinal deformity.

Background Context: The treatment of adolescent congenital deformity (late-diagnosed congenital deformity) is still unknown. The best candidates for hemivertebra excision are young patients, typically between 4 and 6 years of age. Partial excision may be feasible for older children.

Rectal perforation after procedure for prolapse and hemorrhoids: possible causes.

Purpose: Our aim was to explore possible causes of rectal perforation occurring in patients who undergo the procedure for prolapse and hemorrhoids.

Methods: We evaluated data from cases of rectal perforation that occurred after the procedure for prolapse and hemorrhoids in China in conjunction with case reports from the international medical literature.

Results: We identified 7 patients from 5 hospitals in 2 provinces of China who had rectal perforation after the procedure despite having received prophylactic antibiotic treatment.

[Effect of colonoscopy combined with placement of metallic clips on selecting colonic surgery incision].

Objective: To evaluate the accuracy and value of the placement of metallic clips during colonoscopy in the localization of colorectal cancer and incision selection.

Methods: A total of 30 patients received metallic clip placement by colonoscopy before operation. Abdominal plain film (supine and upright position) was taken and incision was determined by the projection of clips on the abdominal wall.

Diagnosis and treatment of diffuse cavernous hemangioma of the rectum: report of 17 cases.

Background: Diffuse cavernous hemangioma of the rectum (DCHR) is a rare benign vascular disease, which is often misdiagnosed and difficult to treat.

Methods: Seventeen cases of DCHR in our hospitals from 1995 to 2009 were identified. The detailed data of diagnosis, treatment, and prognosis were carefully studied.

[Factors associated with anastomotic leakage after anterior resection in rectal cancer].

Objective: To analyze the factors associated with anastomotic leakage after anterior resection in rectal cancer with the technique of total mesorectal excision (TME).

Methods: From January 2005 and December 2007, 738 consecutive patients with rectal cancer underwent anterior resection. The data of those patients was collected and reviewed retrospectively.

Influencing factors of symptomatic anastomotic leakage after anterior resection of the rectum for cancer.

Background: The aim of the present study was to analyze the factors associated with anastomotic leakage after anterior resection for rectal cancer.

Methods: Retrospectively collected consecutive data of 738 rectal cancer patients who underwent anterior resection in our hospital between 2005 and 2008 were reviewed. The associations between 15 patient-related and surgery-related variables and anastomotic leakage were studied with both the univariate chi-square test and multivariate logistic regression analysis.

[Pull-through transection and anastomosis for early lower rectal cancer using double stapling technique].

Objective: To introduce the experiences of pull-through transection and double stapling anastomosis for early lower rectal cancer.

Methods: From May 2001 to March 2008, 25 patients with early stage lower rectal cancer were operated by using pull-through transection and double stapling anastomosis. The average distance between the dentate line and lower margin of the tumor is (3.

[Diagnosis and surgical management for adult Hirschsprung's disease].

Objective: To investigate the diagnosis and surgical management of adult Hirschsprung's disease.

Methods: Clinical data of 15 patients with adult Hirschsprung's disease were reviewed retrospectively from June 1992 to June 2004.

Results: Patients age ranged from 17 to 54 years old.

[Application of positron emission tomography in diagnosis of liver metastases from colorectal cancer].

Objective: To evaluate the value of positron emission tomography (PET) in diagnosing liver metastases from colorectal cancer.

Methods: Eighteen patients suspected with liver metastases after resection of colorectal cancer and three patients suspected with other diseases were diagnosed by PET and CT before operation. The result of both diagnostic approaches was compared with the result of exploratory operation.

c-src activating mutation analysis in Chinese patients with colorectal cancer.

Aim: To investigate the occurrence of cellular src (c-src) activating mutation at codon 531 in colorectal cancer patients from Chinese mainland.

Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay followed by sequencing and single-strand conformation polymor-phism analysis were carried out to screen 110 samples of primary colorectal cancer and 20 colorectal liver metastases.

Results: Only one sample showed PCR-RFLP-positive results and carried somatic codon 531 mutations.