Publications by authors named "Han-mei Lou"
Article Synopsis
- HPV is the main cause of cervical cancer, and current vaccines primarily target HPV types 16 and 18, which may not be adequate for regions like China due to different HPV genotype distributions.
- A study of 5,410 women with cervical cancer found that HPV-16 and -18 were responsible for significant percentages of various cancer types, but low-risk types included in the vaccine were less effective.
- Adding HPV types 52 and 58 to the vaccine could enhance protection against cervical cancer and pre-cancerous conditions, suggesting a need for a more tailored vaccine for better efficacy in the Zhejiang Province.
Article Synopsis
- The study explored the importance of detecting micrometastasis in sentinel lymph nodes (SLN) of patients with early cervical cancer by analyzing lymph nodes collected during surgery.
- A total of 268 lymph nodes were examined, revealing a high sensitivity (66.7%) and accuracy (96.4%) for SLN detection, but also a significant false negative rate (16.7%) for micrometastasis identified by advanced PCR methods.
- The findings indicated that micrometastasis is prevalent even in lymph nodes that appear pathologically negative, with a crucial relationship between SLN micrometastasis and the presence of more extensive lymph node involvement.
[Clinical significance of serum proteomic profiling before and after cervical cancer surgery].
Zhonghua Fu Chan Ke Za Zhi
May 2009
Objective: To investigate the value of serum proteomic profiling in cervical cancer detected pre-surgery and post-surgery.
Methods: Magnetic bead and matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) were used to detect the serum samples from 54 cases with cervical cancer before and after surgery and 53 serum samples from healthy women. The results of spectra were analyzed by Biomarker Wizard software.
[Sentinel lymph node detection and intra-operational diagnosis in patients with early stage cervical cancer].
Zhonghua Yi Xue Za Zhi
December 2007
Objective: To study the effective method for rapid detection of sentinel lymph nodes in patients with early stage cervical cancer and clinical value thereof.
Methods: Thirty female patients with early stage cervical cancer, 14 at FIGO stage IB1 and 16 at stage IIA, underwent injection of 99mTc-labelled sulfur colloid 0.4 mci/0.
Background & Objective: Lymphatic metastasis is the major recurrent way in invasive cervical carcinoma. This study was to summarize the characteristics, treatment, and prognosis of lymphatic metastasis in invasive cervical carcinoma patients after initial treatment.
Methods: Clinical data of 123 invasive cervical carcinoma patients with lymphatic metastasis after initial treatment at Zhejiang Provincial Cancer Hospital between 1990 and 2000 were analyzed.
Article Synopsis
- * Common characteristics included small tumor size (average diameter of 7 cm) and a high rate of infertility (40.7%), with many patients presenting with early stage I lesions (66.7%).
- * Surgical treatment followed by chemotherapy yielded a 3-year survival rate of 66.7%, indicating that this type of cancer, while complex, often has a favorable prognosis when detected early.