Short-term exposure to gaseous pollutants is neglected factors for knee osteoarthritis: evidence from a humid subtropical region of China.

Few studies were performed on the impact of exposure to gaseous pollutants on the risk of knee osteoarthritis (KOA). We conducted this study to analyze the association between short-term exposure to gaseous pollutants and the risk of hospitalizations for KOA. A total of 2952 KOA hospitalizations derived from two hospitals in Hefei, and the relationship between gaseous pollutants and KOA hospitalizations was analyzed by a distributed lag non-linear model combined with a generalized linear model.

Synthesis and Biological Evaluation of Steviol Derivatives with Improved Cytotoxic Activity and Selectivity.

Steviol is an -kaurene diterpenoid with interesting pharmacological activity. Several steviol derivatives with an -methylene cyclopentanone unit were discovered as potent antitumor agents. However, their poor selectivity for tumor cells relative to normal cells reduces their prospects as potential anticancer drugs.

Transcriptome Analysis Reveals Molecular Underpinnings of Common Carp () Under Hypoxia Stress.

As an essential environmental factor that affects the economic benefits of aquaculture, hypoxia is one of the urgent problems to be solved in the aquaculture fish breeding industry. Common carp () is a critical economic fish in China, and at present, there are many breeding strains of common carp with different character advantages in China, including Hebao red carp ( var ) and Songpu mirror carp ( var ). Even if the environmental adaptation of common carp is generally strong, the genetic background of hypoxia tolerance in different strains of common carp is unclear yet.

iGRLCDA: identifying circRNA-disease association based on graph representation learning.

While the technologies of ribonucleic acid-sequence (RNA-seq) and transcript assembly analysis have continued to improve, a novel topology of RNA transcript was uncovered in the last decade and is called circular RNA (circRNA). Recently, researchers have revealed that they compete with messenger RNA (mRNA) and long noncoding for combining with microRNA in gene regulation. Therefore, circRNA was assumed to be associated with complex disease and discovering the relationship between them would contribute to medical research.

A reference framework for health and safety in the workplace in China and the European Union: A comparative study.

Background: Occupational Health and Safety (OHS) has a direct repercussion on the work, social and economic environments. The regulatory frameworks developed by each country are a basic aspect of OHS action policies.

Objective: This study analyses and compares the differences in OHS regulations in China and the European Union (EU) to identify weaknesses or gaps in the Chinese regulations.

Population genetic analysis of aquaculture salmonid populations in China using a 57K rainbow trout SNP array.

Various salmonid species are cultivated in cold water aquaculture. However, due to limited genomic data resources, specific high-throughput genotyping tools are not available to many of the salmonid species. In this study, a 57K single nucleotide polymorphism (SNP) array for rainbow trout (Oncorhynchus mykiss) was utilized to detect polymorphisms in seven salmonid species, including Hucho taimen, Oncorhynchus masou, Salvelinus fontinalis, Brachymystax lenok, Salvelinus leucomaenis, O.

Understanding the commonalities and differences in genomic organizations across closely related bacteria from an energy perspective.

The availability of a large number of sequenced bacterial genomes facilitates in-depth studies about why genes (operons) in a bacterial genome are globally organized the way they are. We have previously discovered that (the relative) transcription- activation frequencies among different biological pathways encoded in a genome have a dominating role in the global arrangement of operons. One complicating factor in such a study is that some operons may be involved in multiple pathways with different activation frequencies.

Mechanistic studies of an unusual epoxide-forming elimination of a beta-hydroxyalkyl rhodium porphyrin.

A new and remarkably facile sp3-C-O bond forming reaction of beta-hydroxyalkyl Rh porphyrins to form epoxides has been discovered and its mechanism investigated.