Publications by authors named "Han-Ye Liu"
Pathol Res Pract
June 2022
Article Synopsis
- Macrophages play a crucial role in diseases related to inflammation, and this study focuses on how Notch signaling is involved when TLR4, a receptor activated by bacteria, stimulates these cells.
- The researchers found that when macrophages were stimulated with lipopolysaccharide (LPS), there was an increase in Notch1 expression and its target genes, indicating that TLR4 enhances Notch signaling in inflammatory responses.
- By inhibiting Notch signaling with a specific drug (DAPT), the study showed reduced levels of pro-inflammatory proteins and disrupted an important pathway (NF-κB) that is usually activated during TLR4 signaling, suggesting that targeting Notch1
