Publications by authors named "Han-Ya Lin"
Article Synopsis
- - The study investigates the relationship between tumour mutation burden (TMB) and the prognosis of patients with stage III gastric cancer, finding that high TMB correlates with better overall survival rates.
- - Patients were categorized into high and low TMB groups using genetic sequencing and analysis, revealing that age is a key independent factor influencing prognosis, while TMB plays a significant, but secondary role.
- - The research identifies that genes frequently mutated in gastric cancer are associated with certain signaling pathways, suggesting that TMB could serve as a useful biomarker for clinical outcomes in these patients.
Article Synopsis
- Cyclodextrins (CDs) incorporated in nanofiber membranes can effectively remove steroid hormone micropollutants from water, with the study focusing on how different types of CDs (α, β, γ) influence this process.
- The study found that the αCDP consistently removed 33-50% of SHs, while β and γCDPs showed varying efficiencies, with the highest removal at 74% for progesterone.
- Molecular dynamics simulations revealed that βCDP forms stronger and more stable complexes with SHs compared to α and γCDP, indicating the importance of CD type in developing efficient filtering membranes for water treatment.
Article Synopsis
- - Photocatalytic membrane reactors (PMRs) show potential for removing micropollutants, like steroid hormones, by utilizing sunlight, though effectiveness is influenced by catalyst properties and conditions.
- - A new poly(vinylidene fluoride) nanofiber composite membrane (PVDF-BMCN) was developed, demonstrating that an increased visible-light-responsive catalyst ratio improved estradiol degradation from 20% to 75%.
- - Optimal results were achieved with specific conditions: a removal rate of 96% at a low concentration of E2, when factors like hydraulic residence time, light intensity, and BMCN catalyst loading were properly adjusted.
Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer.
World J Gastroenterol
April 2019
Background: Gastric cancer (GC) is one of the main causes of cancer mortality worldwide. Recent studies on tumor microenvironments have shown that tumor metabolism exerts a vital role in cancer progression.
Aim: To investigate whether lysyl oxidase (LOX) and hypoxia-inducible factor 1α (HIF1α) are prognostic and predictive biomarkers in GC.