Publications by authors named "Han-Xiao Zhou"
Article Synopsis
- This study analyzes the proteomic profiles of three main types of epithelial ovarian cancer (Clear cell carcinoma, Endometrioid carcinoma, and Serous carcinoma) using 80 samples of CCC, 79 samples of EC, and 80 samples of SC, along with 30 control samples.
- The research identifies significant differences in protein expression and phosphorylation that could help in diagnosing and predicting outcomes for each cancer subtype.
- Importantly, the findings suggest that MPP7 protein could serve as a potential therapeutic target for Serous carcinoma, enhancing our understanding of the distinct biological features and treatment options for these cancers.
Article Synopsis
- - This study focuses on the role of long non-coding RNAs (lncRNAs) in relation to metabolic risk factors for coronary artery disease (CAD), analyzing data from patients with CAD and healthy controls through high throughput sequencing and validation with qRT-PCR.
- - Out of over 26,000 lncRNAs identified, 2,149 were found to be differentially expressed in CAD patients, with PDXDC1-AS1 and SFI1-AS1 showing significant differences and potential as diagnostic biomarkers.
- - The analysis revealed that PDXDC1-AS1 and SFI1-AS1 not only differentiate CAD patients from controls but also indicate protective effects against CAD and significant interactions with environmental risk factors like smoking. *
The aim of this study is to investigate mRNA expression profiling by RNA sequencing (RNA-seq) in patients with coronary artery disease (CAD) and validate differentially expressed genes (DEGs) as novel biomarkers for CAD. Transcriptome-wide mRNA expression analysis of peripheral blood mononuclear cells was performed in five CAD patients and five controls. Functional enrichment analyses, protein-protein interaction network construction, and hub gene selection were further conducted.
View Article and Find Full Text PDFCircular RNAs (circRNAs) function as promising biomarkers and therapeutic targets for coronary artery disease due to their high stability, covalently closed structure, and potential gene regulation. We aimed to identify the expression profile and role of circular RNAs (circRNAs) in coronary artery disease (CAD). We performed RNA sequence analysis of circRNAs in peripheral blood mononuclear cells of five patients with CAD and five controls.
View Article and Find Full Text PDFA fully automated method for identification and quantification of five polar pesticides in groundwater by isotope dilution-online solid-phase extraction (SPE) coupled with high-performance liquid chromatography-quadrupole Orbitrap high-resolution mass spectrometry was developed. After one step of filtration, an aliquot of a 7.5-ml water sample was automatedly preconcentrated and purified on a turbulent Cyclone SPE column.
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- The study aimed to explore how miRNA-101 affects the expression of the EZH2 protein in human prostate cancer cells (LNCaP).
- Using fluorescence microscopy and qRT-PCR, researchers confirmed successful transfection of miRNA-101 and measured its impact on EZH2 mRNA and protein levels in different cell groups.
- Results showed that miRNA-101 significantly reduced EZH2 expression, suggesting its potential as a therapeutic approach for treating prostate cancer.