Sentinel lymph node biopsy versus elective neck dissection in patients with cT1-2N0 oral tongue squamous cell carcinoma.

Objective: This study aimed to compare the value of sentinel lymph node biopsy (SLNB) with that of elective neck dissection (END) for the prediction of cervical lymph node metastasis in patients with clinically diagnosed T1-2N0 (cT1-2N0) oral tongue squamous cell carcinoma (OTSCC), and it aimed to examine the prognostic value of individualized treatment in sentinel lymph node (SLN)-negative patients.

Study Design: The study entailed a retrospective review of 82 patients with cT1-2N0 OTSCC. Thirty patients underwent SLNB, and 52 patients underwent END.

Immediate reconstruction of maxillectomy defects using anterolateral thigh free flap in patients from a low resource region.

Objectives/hypothesis: To report the reliability and reconstructive outcome of using anterolateral thigh (ALT) flap with or without titanium mesh to repair maxillectomy defects in a patient from a low resource region (LRR).

Study Design: Retrospective review.

Methods: Clinical data of patients with oral-maxillofacial cancers who underwent maxillectomy and reconstruction using ALT flap in two tertiary cancer centers in southern China were retrospectively reviewed.

[Sentinel lymph node radiolocalization in squamous cell carcinoma of the oral tongue].

Background & Objective: At present, there is no clinical examination that can accurately assess the lymph node metastasis status of oral tongue carcinoma with clinically negative neck lymph node (cN0) before operation. Therefore, the treatment of cN0 neck is still controversial. Sentinel lymph node (SLN) biopsy may be the evidence for individual treatment of cN0 neck.

[Research of modified rat laryngeal transplantation model].

Objective: To study modified rat laryngeal transplantation model.

Methods: Eighty isogeneic histocompatible F344 rats were randomized into control and experimental groups. Strome model of laryngeal transplantation was established in the the control group, and in the experimental group, the ascending pharyngeal artery was preserved and the base of the tongue, larynx and pharyngolarynx were harvested as a complex allograft followed by end-to-end anastomosis of the both allograft common carotid arteries with the recipient common carotid artery and the anterior jugular vein, respectively.

[In vitro preservation of laryngeal allograft for larynx transplantation].

Background & Objective: As a complex organ, laryngeal allograft cannot endure more than 3 hours during preservative time in vitro. This study was to explore the best preservation method and time limit of laryngeal allograft.

Methods: During transplantation experiment of the larynx, HCA solution and UW's solution was used to perfuse laryngeal allograft on original position separately.

[Establishment of a modified larynx transplantation model with inbred F344 rat].

Background & Objective: As a non-vital organ, transplantation of larynx lags behind that of the other organs, but it is supposed that if induction of immunologic tolerance of the host to the allograft comes true, larynx transplantation would be an optimal approach for management of advanced laryngeal cancer as well as functional reconstruction of the larynx. This study was designed to establish a modified rat model of larynx transplantation to improve survival rate of the recipients and vitality of the allografts, and provide an optimal rat model for further research on immunology and induction of immunologic tolerance in larynx transplantation.

Methods: A Strome's model of larynx transplantation was repeated with inbred F344 rats (40 rats in Stroma model A and 40 rats in Stroma model B).

[Management option for cervical metastases in tongue squamous cell carcinoma with clinically N0 neck].

Objective: This study was designed to explore the optimal management option for cervical metastases in tongue squamous cell carcinoma (SCC) with clinically N0 neck in order to avoid excessive or inadequate treatment in clinical practice.

Methods: Clinical data of 327 cases of tongue SCC with cN0 neck were retrospectively analyzed. Neck control rates affected by different pathoclinical parameters were compared.

[Treatment and prognosis of stage T3 glottic laryngeal cancer--a report of 65 cases].

Background & Objective: Clinical treatment of stage T3 glottic laryngeal cancer still remains controversial. This study was to explore the influences of different treatment modalities, lymph node metastasis, and positive margin on prognosis of stage T3 glottic cancer.

Methods: Records of 65 stage T3 glottic cancer patients, treated in Cancer Center of Sun Yat-sen University from Jan.

[Surgical management for occult cervical metastasis of oral tongue squamous cell carcinoma].

Background & Objective: In oral tongue squamous cell carcinoma (SCC), the management for clinically negative (cN0) neck remains controversial. This study was to explore rational neck management for cN0 cases.

Methods: Clinical data of 187 patients with oral tongue SCC of cN0, who received surgery alone, were retrospectively reviewed.

[Clinical research of sentinel node biopsy in oral tongue carcinoma].

Objective: This study was designed to evaluate whether sentinel node (SN) biopsy can accurately assess the cervical lymph node status of oral tongue carcinoma, as well to research the best method and indications of SN biopsy.

Methods: Preoperative lymphoscintigraphy with (99m)Tc-SC and intraoperative sentinel node mapping with methylene blue dye were administered on 20 cases of oral tongue carcinoma with cN(0) neck and 5 cases with cN(+) neck; routine pathological examination was used to assess the status of SNs. The results of routine pathological examination of cervical specimen were set as golden standard to assess the efficacy of SN biopsy in evaluating the cervical lymph node status.

[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma].

Background & Objective: The prognosis of supraglottic squamous cell carcinoma (SGSCC) was poor. To authors' knowledge, the relationship between inducible nitric oxide synthase (iNOS) and basic fibroblast growth factor (bFGF) and the prognosis of SGSCC has not been addressed to date. This study was designed to evaluate the prognostic significance of these two parameters in SGSCC.

[Diagnosis of unknown primary cervical metastatic carcinoma].

Theoretically, primary carcinomas affirmatively exist when a cervical metastasis is diagnosed. However, not all primary carcinoma can be detected under present examination practically. Whether the primaries are found affects the outcomes of long-term survival and quality of life of the patients.

[Optimized methods of sentinel node localization in cN0 tongue carcinoma].

Background & Objective: At present, there is no clinical examination and biochemical marker available to assess the lymph node status of tongue carcinoma with clinically negative neck (cN0) accurately. Therefore, the treatment of the cN0 neck in tongue carcinoma is of blind to some extent. Application of sentinel node(SN) biopsy may possibly bring about the individualized management of the cN0 neck of tongue carcinoma.

[Regularity and therapeutic strategy of cervical lymph node metastasis in squamous cell carcinoma of the tongue].

Background & Objective: At present, whether neck dissection should be employed in squamous cell carcinoma (SCC) of the tongue with clinically node negative neck(cN0) is still controversial. This study was designed to explore the regularity of cervical lymph node metastasis in SCC of the mobile part of the tongue, and to discuss the theories and principles of employment of selective neck dissection in cN0 cases.

Methods: A retrospective research was performed on clinical data of 214 cases of SCC of the tongue treated with surgery from 1991 to 1997.