Network pharmacology analysis and experimental validation to explore the mechanism of Hanchuan Zupa Granule in asthma.

Ethnopharmacological Relevance: Hanchuan Zupa Granule (HCZP) is a classic prescription of Uyghur medicine, that is used for cough and abnormal mucinous asthma caused by a cold and "Nai-Zi-Lai".

Aim Of The Study: This study aimed to explore the possible molecular mechanism of HCZP in the treatment of asthma, using a network pharmacology method and in vivo experiments.

Materials And Methods: First, we conducted qualitative analysis of the chemical composition of HCZP as a basis for network pharmacology analysis.

Competitive CatSper Activators of Progesterone from Rhynchosia volubilis.

The root was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in plants. Interestingly, these nonphysiological ligands would also disturb the activation of the cation channel of sperm induced by progesterone.