Publications by authors named "Han-Ming Huang"
Article Synopsis
- The study aimed to assess changes in liver and kidney function, as well as red blood cell count and hemoglobin levels, in patients after undergoing ultrasound-guided percutaneous microwave ablation (UPMWA) for uterine fibroids, with evaluations done on postoperative day 1.
- A review of 181 patients treated between August 2017 and January 2023 revealed significant increases in certain liver function markers and decreases in protein levels and RBC count after the procedure, indicating a strain on liver functions and potential risks to kidney health.
- The findings suggest that while UPMWA is effective in treating uterine fibroids, it may lead to temporary organ stress; thus, protective measures during the perioperative period are recommended to support
Article Synopsis
- - Background studies show that the kappa opioid receptor (KOR) might be crucial in understanding and treating esophageal squamous cell carcinoma (ESCC), but its specific effects on tumor progression are not fully known.
- - The research compared KOR gene expression in cancerous vs. normal tissues, revealing lower KOR levels linked to worse survival rates; experiments indicated that lowering KOR increased cancer cell growth, spread, and invasion abilities.
- - Mechanistically, reduced KOR activates the PDK1-AKT signaling pathway, facilitating tumor invasion and changes in the cytoskeleton, evidenced by alterations in protein interactions and cellular structures during the tests conducted in both lab and animal models.
Article Synopsis
- Parecoxib has potential as a treatment for esophageal squamous cell carcinoma (ESCC), but its specific effects and mechanisms were previously unclear.
- The study showed that parecoxib causes G2 phase cell cycle arrest and reduces cell growth, invasion, and migration in ESCC through various experimental methods, including RNA sequencing and assays.
- Results indicated that parecoxib affects cancer-related proteins and signaling pathways, particularly inhibiting MMP2 secretion and tumor growth, highlighting its role in suppressing ESCC progression via the PDK1-AKT pathway.
Background: There are limited data on the trends of incidence or prevalence of end stage renal disease (ESRD) in China. To assist in future planning for the ESRD program, the trends of incidence, prevalence and health care costs were analyzed and forecasted to the year 2025 by modeling of historical data from 2004 through 2014.
Methods: Nanjing urban employee basic medical insurance (NJUEBMI) data were obtained from the Nanjing Medical Insurance Information System from 2004 to 2014.
Background: The growing burden of end-stage renal disease (ESRD) has been a great challenge to the health care system of China. However, the exact epidemiological data for ESRD in China remain unclear. We aimed to investigate the epidemiology of ESRD treated by renal replacement therapy (RRT) in Nanjing based on analysing ten-year data of Nanjing three million insurance covered population.
View Article and Find Full Text PDF