Publications by authors named "Han-Lun Yang"
J Clin Pharm Ther
November 2022
Article Synopsis
- Olanzapine is an atypical antipsychotic used for mental disorders, but there's limited pharmacokinetic data for Chinese pediatric patients aged 10 to 17 years, which raises questions about dosage variability.
- A study collected therapeutic drug monitoring data from 151 pediatric patients and developed a model using NONMEM software to simulate dosing regimens, targeting a concentration level of 20 ng/ml.
- The final model identified sex and concomitant valproate as significant factors affecting olanzapine clearance, suggesting specific daily dosages for male and female patients, which can assist physicians in dosage adjustments.
