Publications by authors named "Han-Lin Zhang"

We aimed to analyze the clinical profile and malignancy indicators in dermatomyositis (DM) with anti-transcriptional intermediary factor 1 antibody (anti-TIF1γ-Ab). A comparison was made between clinical information of anti-TIF1γ DM patients with and without malignancy. Additionally, a review of the literature on anti-TIF1γ DM and malignancy was conducted by searching PubMed and EMBASE databases.

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  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions linked to immune checkpoint inhibitors (ICIs) in cancer patients, forming the focus of this systematic review which compiles existing research on their impact.
  • The analysis included data from 47 articles covering 50 patients, primarily with melanoma or non-small cell lung cancer, revealing that SJS/TEN typically appears within 23 days after starting ICIs, with a notable mortality rate of 20%.
  • Treatment often involved corticosteroids and immunoglobulins, and the study found correlations between the severity of skin detachment and outcomes, with higher mortality associated with TEN as opposed to SJS, and a median re-
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  • The study investigates the viscoelastic properties and asymmetrical behavior of the intervertebral disc under different mechanical loads, which is crucial for understanding lumbar disc injuries.
  • Experiments involving sheep intervertebral disc samples reveal that tensile stiffness is significantly lower than compressive stiffness, and the relation between elastic modulus and strain rate is linear, indicating distinct tension-compression asymmetry.
  • The results also show that stress-strain curves for loading and unloading create a hysteresis loop (Mullins effect), and the introduction of a damage factor in the constitutive equation accurately captures the disc's rate-dependent behavior.
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Proteins must be sorted to specific subcellular compartments to perform their functions. Abnormal protein subcellular localizations are related to many diseases. Although many efforts have been made in predicting protein subcellular localization from various static information, including sequences, structures and interactions, such static information cannot predict protein mis-localization events in diseases.

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We analyzed the particle size distribution of soil aggregates in 0-20 and 20-40 cm soil layers of rice-wheat rotation field based on a field plot test with two treatments, conventional straw returning (CK) and straw returning with the addition of straw decomposition promoting microbial inoculants (IT). We evaluated the water stability indices of soil aggregates (the number of soil water stable large aggregates , the average weight diameter MWD, and the geometric average diameter GMD), and measured the contents of soil organic carbon (SOC), total nitrogen (TN), and total phosphorus (TP) in the soil aggregates of <0.053, 0.

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Molecular weight is one of the main characteristic parameters of proteins, which is the basis for the functional properties of milk protein. This research aims at establishing molecular weight distribution pattern of milk protein based on exclusion chromatography. The method selected NaPO-NaSO (0.

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  • * Research using ELISA showed that HHP treatments (100-600 MPa) significantly reduced the antigenicity of β-LG, particularly at pressures above 300 MPa, which also caused molecular changes that enhanced digestibility.
  • * The study found that HHP treatment increased the antioxidant properties and emulsion stability of WPI, as pressure-induced structural changes led to higher levels of α-helix and β-turns, while decreasing β-sheet content.
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Background: The transforming growth factor β (TGFβ) signaling pathway plays a crucial role in the development of liver fibrosis by activating TGFβ type II receptor (TGFβR2), followed by the recruitment of TGFβR1 finally triggering downstream signaling pathway.

Aim: To find drugs targeting TGFβR2 that inhibit TGFβR1/TGFβR2 complex formation, theoretically inhibit TGFβ signaling pathway, and thereby ameliorate liver fibrosis.

Methods: Food and Drug Administration-approved drugs were screened for binding affinity with TGFβR2 by virtual molecular docking.

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The development of food-derived Xanthine Oxidase (XO) inhibitors is critical to the treatment of hyperuricemia and oxidative stress-related disease. Few studies report on milk protein hydrolysates' XO inhibitory activity, with the mechanism of their interaction remaining elusive. Here, different commercial enzymes were used to hydrolyze α-lactalbumin and bovine colostrum casein.

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The aberrant protein sorting has been observed in many conditions, including complex diseases, drug treatments, and environmental stresses. It is important to systematically identify protein mis-localization events in a given condition. Experimental methods for finding mis-localized proteins are always costly and time consuming.

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Binding to phenolics can improve the functional properties of proteins. Changes in structure, functional properties, and antigenicity of β-lactoglobulin (β-LG) after covalent conjugation with ferulic acid (FA) at different mass ratios were reported here. The results of SDS-PAGE and gel exclusion chromatography confirmed that covalent complexes were formed.

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Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance in domestic animals, we sequenced the genomes of 28 cattle from warm and cold areas across China. By characterizing the population structure and demographic history, we identified two genetic clusters, i.

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The loss of function of melanocytes leads to vitiligo, which seriously affects the physical and mental health of the affected individuals. Presently, there is no effective long-term treatment for vitiligo. Therefore, it is imperative to develop a convenient and effective treatment for vitiligo.

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The problems caused by the interaction between slopes and hydrologic environment in traffic civil engineering are very serious in the granite residual soil area of China, especially in Guangdong Province. Against the background of two heavy rainfall events occurring during a short period due to a typhoon making landfall twice or even two typhoons consecutively making landfall, laboratory model tests were carried out on the hydrological effects of the granite residual soil slope considering three vegetation types under artificial rainfall. The variation in slope surface runoff, soil moisture content and rain seepage over time was recorded during the tests.

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Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the atranones (1-5) were evaluated against MG-63 human osteosarcoma cell lines.

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Moisture content is an important factor in corn breeding and cultivation. A corn breed with low moisture at harvest is beneficial for mechanical operations, reduces drying and storage costs after harvesting and, thus, reduces energy consumption. Nondestructive measurement of kernel moisture in an intact corn ear allows us to select corn varieties with seeds that have high dehydration speeds in the mature period.

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