Publications by authors named "Han-Jia Zhang"
Article Synopsis
- Traditional immune checkpoint therapies show limited effectiveness for some cancers, particularly pancreatic adenocarcinoma (PAAD), highlighting the need for new therapeutic targets.
- Researchers discovered that Neuropilin (NRP) is highly expressed in tumor tissues of PAAD, correlating with poor patient outcomes and less effective responses to existing treatments.
- Bioinformatics and experimental studies indicate that NRPs, especially NRP1, play significant roles in tumor development and could serve as valuable biomarkers and therapeutic targets for cancers.
Objective: To explore the effects of neural respiratory drive on ventilation in patients with chronic obstructive pulmonary disease (COPD) during sleep.
Methods: Diaphragm electromyogram (EMG) from a multipair esophageal electrodes and airflow derived from pneumotachography were recorded during overnight polysomnography in 13 patients with stable COPD recruited from outpatient clinic of First Affiliated Hospital of Guangzhou Medical College from May 2010 to May 2011. Changes in diaphragm EMG and ventilation during wakefulness and different sleep stages were observed.