Publications by authors named "Han-Fen Shi"
Vascular and neurological damage are the typical outcomes of ischemic strokes. Vascular endothelial cells (VECs), a substantial component of the blood-brain barrier (BBB), are necessary for normal cerebrovascular physiology. During an ischemic stroke (IS), changes in the brain endothelium can lead to a BBB rupture, inflammation, and vasogenic brain edema, and VECs are essential for neurotrophic effects and angiogenesis.
View Article and Find Full Text PDFPericytes, as the mural cells surrounding the microvasculature, play a critical role in the regulation of microcirculation; however, how these cells respond to ischemic stroke remains unclear. To determine the temporal alterations in pericytes after ischemia/reperfusion, we used the 1-hour middle cerebral artery occlusion model, which was examined at 2, 12, and 24 hours after reperfusion. Our results showed that in the reperfused regions, the cerebral blood flow decreased and the infarct volume increased with time.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on optimizing the extraction process of a traditional Chinese medicine, Tuomin Dingchuan Prescription, by identifying critical process parameters (CPPs) and critical quality attributes (CQAs) to ensure stable efficacy.
- - Key CPPs included extraction times, extraction duration, and water ratio, while the important CQAs identified were the extraction amount of solid matter and amygdalin content, found through experiments like variance analysis.
- - The optimal extraction method was defined as soaking the herbs in water for 30 minutes, extracting three times for 100 minutes each using 10 times the water volume, while the forming process for Tuomin Dingchuan granules required a specific ratio of dry extract to excipient and ethanol for