Necrostatin-1 prolongs latency to convulsion in mice exposed to high oxygen partial pressure.

Introduction: Exposure to very high oxygen partial pressure may cause central nervous system oxygen toxicity (CNS-OT). The role of necroptosis in the pathogenesis of CNS-OT is still unclear.

Methods: In experiment one, male C57BL/6 mice in the oxygen toxicity (OT) group (n = 5) and necrostatin-1 (Nec-1; a necroptosis inhibitor) (1.

Chemical constituents of (Kom.) Nakai and their cytotoxic activities.

A new diarylheptanoid, (1 ,2,3,5)-2,3-dihydroxy-3',3''-dimethoxy-4'-de--methylcentrolobine () and a new bisabolane-type sesquiterpenoid, (1 ,7)-1,12,13-trihydroxybisabola-3,10-diene (), together with nineteen known compounds (-) were isolated from the EtOH extract of the stems and branches of (Kom.) Nakai. Their structures were elucidated by extensive analysis of 1 D and 2 D NMR spectra and from the HRESIMS.

Triterpenoid saponins from the pulp of Sapindus mukorossi and their antifungal activities.

Under the guidance of anti-fungal bioassay, four previously undescribed oleanane-type and one lupane-type triterpenoid saponins, along with twelve known analogues, were isolated from the extract of Sapindus mukorossi pulps. Their structures were determined on the basis of spectroscopic analysis and chemical methods. In vitro biotests, oleanolic acid 3-O-β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranoside showed inhibitory activity against Trichophyton rubrum with MIC value of 8 μg/mL, while oleanolic acid 3-O-α-L-arabinopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranoside exhibited inhibitory activity against both Trichophyton rubrum and Candida albicans with MIC values of 8 μg/mL.