Publications by authors named "Han van de Sandt"
Synthetic amorphous silica is a nanostructured material, which is produced and used in a wide variety of technological applications and consumer products. No regulatory prenatal toxicity studies with this substance were reported yet. Therefore, synthetic amorphous silica was tested for prenatal toxicity, according to OECD guideline 414 in Wistar rats following oral (gavage) administration at the dose levels 0, 100, 300, or 1000mg/kg bw/d from gestation day 6-19.
View Article and Find Full Text PDFSynthetic amorphous silica (SAS) like NM-200 is used in a wide variety of technological applications and consumer products. Although SAS has been widely investigated the available reproductive toxicity studies are old and do not cover all requirements of current OECD Guidelines. As part of a CEFIC-LRI project, NM-200 was tested in a two-generation reproduction toxicity study according to OECD guideline 416.
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- Several cationic amphiphilic compounds can cause phospholipidosis, leading to the accumulation of phospholipids in cells, which gives them a foamy look and affects cellular functions.
- * In a study involving gepirone and other related compounds, researchers conducted physicochemical calculations to analyze their molecular properties, focusing on aspects like molecular weight and partition coefficients.
- * The results showed distinct clustering for amphiphilic drugs compared to piperazines, with lamellar inclusion bodies observed in some compounds but not in others, supporting the use of physicochemical calculations to identify phospholipidosis inducers.