Dynamic phase transitions dictate the size effect and activity of supported gold catalysts.

The landmark discovery of gold catalysts has aroused substantial interest in heterogeneous catalysis, yet the catalytic mechanism remains elusive. For carbon monoxide oxidation on gold nanoparticles (NPs) supported on ceria surfaces, it is widely believed that carbon monoxide adsorbs on the gold particles, while the reaction occurs at the gold/ceria interface. Here, we have investigated the dynamic changes of supported gold NPs with various sizes in a carbon monoxide oxidation atmosphere using deep potential molecular dynamics simulations.

[HPLC-Q-TOF-MS/MS and network pharmacology reveal absorbed components of Bufei Pills, potential in treating respiratory disorders, and mechanism in recovery stage of COVID-19].

This study employed the methods of serum chemistry, in vivo drug distribution analysis, and network pharmacology to investigate the potential therapeutic effects of Bufei Pills on respiratory disorders and decipher the underlying mechanisms. For the in vivo distribution study, rats were administrated with Bufei Pills, and the absorbed components were analyzed by HPLC-Q-TOF-MS/MS. The results showed that 56 components were present in the rat serum, including neocyclomorusin, asterinin A, neoisostegane, goimisin R, and frehmaglutoside H.

Targeting the brain's glymphatic pathway: a novel therapeutic approach for cerebral small vessel disease.

Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia. Due to its diverse etiologies and complex pathological mechanisms, preventing and treating cerebral small vessel vasculopathy is challenging. Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.

Attention-Based Lightweight YOLOv8 Underwater Target Recognition Algorithm.

Underwater object detection is highly complex and requires a high speed and accuracy. In this paper, an underwater target detection model based on YOLOv8 (SPSM-YOLOv8) is proposed. It solves the problems of high computational complexities, slow detection speeds and low accuracies.

Efficacies of different postoperative radiotherapy techniques in patients with N2 non-small cell lung cancer: a meta-analysis.

Background: With clinical trials on the use of different modern precise radiotherapy techniques in the setting of postoperative radiotherapy (PORT) in N2 non-small cell lung cancer (NSCLC) accumulating, an updated meta-analysis was performed.

Methods: A literature search identified studies that investigated PORT versus non-PORT in N2 NSCLC patients. Overall survival (OS) and locoregional recurrence (LR) were employed.

Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Purpose: This study investigated the relationship between the difference in percent body fat (∆PBF) decrease and the change in the metabolic score for insulin resistance (METS-IR) in Chinese overweight/obese people with combined metabolic dysfunction-associated steatotic liver disease (MASLD) after weight loss.

Patients And Methods: A total of 357 overweight/obese MASLD patients were included using a retrospective study method. The subjects were divided into two groups (< 5% and ≥ 5%) based on the ∆PBF.

Microwave replacing traditional concentrating process to promote the synthesis of mumefural in Prunus mume extract.

Mumefural (MF), the primary functional ingredient of prunus mume extract that enhances blood fluidity, is produced by boiling the prunus mume juice for 24-48 h in a traditional one-step concentration process. Low MF yields and long processing time are two disadvantages of this process. This study introduced microwaves into the traditional one-step concentration process of prunus mume extract for increasing MF content.

​Quantitative assessment of heavy metal concentrations, pollution levels, and sources apportionment in one of China's top 10 most livable cities.

Urban topsoil is not only an essential part of the urban ecosystem, but also a powerful carrier of pollutants in the urban environment. In this paper, 130 topsoil samples from urban area of Xinyang in central-eastern China were selected, the aim is to quantitatively investigate the concentrations, pollution levels, and sources apportionment of 8 heavy metals (HMs, encompassing arsenic (As), cobalt (Co), copper (Cu), chromium (Cr), lead (Pb), nickel (Ni), vanadium (V), and zinc (Zn)) via geochemical method. The main conclusions are as follows.

Association between the Life's essential 8 health behaviors score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease.

Background: The association between Life's Essential 8 (LE8) score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unknown.

Methods: This population-based prospective cohort study analyzed data of participants aged 20-79 years in the National Health and Nutrition Examination Survey from 2005 to 2018, with linked mortality information until 2019. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between different cardiovascular health (CVH) scores and all-cause mortality in participants with MASLD.

The Effects of Non-Pharmacological Therapies for Dysphagia in Parkinson's Disease: A Systematic Review.

Background: Parkinson's disease (PD) is currently the second most common degenerative neurological disorder globally, with aspiration pneumonia caused by difficulty swallowing being the deadliest complication. The patient's subjective experience and the safety of swallowing have been the main focus of previous evaluations and treatment plans. The effectiveness of treatment may be attributed to the brain's ability to adapt and compensate.

Structural basis for Retriever-SNX17 assembly and endosomal sorting.

During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.

Risk factors for nosocomial infection in patients undergoing extracorporeal membrane oxygenation support treatment: A systematic review and meta-analysis.

Objective: To evaluate the risk factors of nosocomial infection during Extracorporeal membrane oxygenation (ECMO) treatment through systematic evaluation and meta-analysis, in order to provide evidence-based basis for clinical treatment and prevention of nosocomial infection during ECMO treatment.

Method: Computer search of Cochrane Library, PubMed, Embase, and Web of Science databases was conducted to establish a database of relevant literature published in March 2023. Two researchers independently screened literature, extracted data, and evaluated quality based on inclusion and exclusion criteria, and then analyzed the data using STATA 14.

The systemic immune-inflammation index and systemic inflammation response index are useful for predicting mortality in patients with diabetic nephropathy.

Background: This study investigated the correlation between the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) and all-cause, cardiovascular, and kidney disease mortality in patients with diabetic nephropathy (DN). It aimed to provide a new predictive assessment tool for the clinic and a scientific basis for managing inflammation in DN.

Methods: The data utilized in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) database, spanning 1999 to 2018.

Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients.

Aims: The study attempted to determine the underlying role and regulation mechanism of 3β-hydroxysterol-Δ24 reductase (DHCR24) in the pathophysiology of cerebral small vessel disease-associated cognitive impairment (CSVD-CI). An RNA high-throughput sequencing and independent verification were conducted to identify potential circRNAs becoming the upstream regulator.

Methods: RNA sequencing was performed in whole-blood samples in cohort 1 (10 CSVD-CI and 8 CSVD with cognitively normal [CSVD-CN] patients).

Experiences of caregivers of children with severe self-injurious behavior: An interpretive, descriptive study.

Aim: To describe the experiences of children with self-injurious behavior (SIB) through the lens of family caregivers to inform the development of relevant interventions.

Method: SIB in children with autism spectrum disorder is challenging to understand and manage. Furthermore, our understanding of the impact of SIB on families is limited.

Association between gut microbiota, plasma metabolites, and ovarian cancer: A Mendelian randomization study.

Numerous studies have demonstrated a correlation between alterations in gut microbiota (GM) and levels of body metabolites in ovarian cancer (OC). However, the specific causal relationships underlying these associations remain unclear. This study utilized summary statistics of GM from the MiBioGen consortium, along with an unprecedented dataset comprising 1091 blood metabolites and 309 metabolite ratios from the UK Biobank, in conjunction with OC data from the FinnGen Consortium R9 release.

Insight into volatile metabolites and key odorants in black teas processed from Jianghua Kucha tea germplasm (Camellia sinensis var. assamica cv. Jianghua).

Jianghua Kucha (JHKC) is an ancient tea germplasm, which presents a high value for resource utilization but was less developed in aroma research. In this study, volatile metabolites in fresh leaves and corresponding black teas of JHKC, along with odorants of JHKC black teas were systematically investigated using stir-bar sorptive extraction in combination with gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry/MS (GC-O/MS) technologies. A total of 128 and 135 volatile compounds were identified in fresh leaves and black teas, respectively, along with 13 key differential volatile components derived from fatty acids, pigments, glycoside precursors, and the terpene pathway.