Biocompatibility of universal dental adhesives: An in vitro study.

Statement Of Problem: Adhesives play an essential role in restorative dentistry, and Universal Bond Quick (UBQ) has been marketed as having a short application time and long-term resistance to hydrolysis. However, research on its biocompatibility is lacking.

Purpose: The purpose of this in vitro study was to compare the biocompatibility of 3 recently introduced universal dental adhesives: UBQ, Single Bond Universal (SBU), and Prime&Bond Universal (PBU), and the popular clinical dental adhesive SE Bond.

The impact of endogenous N/OFQ on DPN: Insights into lower limb blood flow regulation in rats.

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, often accompanied by impaired vascular endothelial function in the lower limbs. This dysfunction is characterized by a reduced vasodilatory response, leading to decreased blood flow in the lower limbs and ultimately contributing to the development of diabetic peripheral neuropathy. To delve deeper into this pathological process, the study employed bioinformatics to identify and analyze genes highly active in DPN.

Activation strategies and effectiveness of Intelligent safety systems for reducing pedestrian injuries in autonomous vehicles.

Intelligent safety systems (ISS) for autonomous vehicles, integrating advanced perception capabilities and passive protection devices, are expected to reshape traditional pedestrian safety systems and play a key role in reducing the risk of pedestrian injuries in traffic accidents. However, traditional active control and passive protection modules remain disconnected due to insufficient evidence supporting the effectiveness of collaborative strategies in integrated systems, particularly concerning activation criteria and timing. This study aims to address this gap by developing a comprehensive ISS that incorporates advanced perception systems, a vehicle dynamic control module, and controllable passive safety devices.

Kilogram Flash Joule Heating Synthesis with an Arc Welder.

Flash Joule heating has been used as a versatile solid-state synthesis method in the production of a wide range of products, including organic, inorganic, and ceramic products. Conventional flash Joule heating systems are large and customized, presenting significant barriers in the cost of assembly, the expertise needed to operate, and uniformity of results between different systems. Even laboratory-scale flash Joule heating systems struggle to operate above 10 g capacity, and they suffer from poor temperature controllability.

Promoted metabolic remolding by overexpression of AspAT9 ameliorates cadmium toxicity in Arabidopsis.

Cadmium (Cd) is a toxic heavy metal that poses a serious threat to crop safety and human health. Aspartate aminotransferase (AspAT) is a prime enzyme engaged in amino acid metabolism, contributing essential metabolic substances for plant growth and acclimatization to various stresses. In this study, we identified a novel AspAT9 gene with high responsiveness to Cd stress from poplar 'Nanlin895' and subsequently transformed it into Arabidopsis.

A novel ratiometric BenzoBODIPY-Based fluorescent probe for the detection and imaging of Cysteine in living cells and zebrafish models.

Cysteine (Cys) plays a critical role in various biological processes, including protein synthesis, cellular signaling, and antioxidant defense. However, precise detection of Cys in biological systems remains challenging due to interference from similar thiols such as homocysteine (Hcy) and glutathione (GSH). In this study, we report the synthesis and bioimaging of a novel ratio-type fluorescent probe based on the benzoBODIPY fluorophore, designed for the ratiometric detection of Cys.

Measurement of pulmonary hematocrit using oscillation of hyperpolarized Xe MR signals in blood.

Purpose: To demonstrate the feasibility of measuring pulmonary hematocrit (Hct) in blood in vivo using oscillation of hyperpolarized Xe MR signals and its potential for disease assessment in animal models.

Methods: Hyperpolarized Xe dynamic MR spectroscopy was performed on 10 anemia model rats and 10 control rats. A concise model based on hyperpolarized Xe MR signal oscillations was built for calculating pulmonary Hct.

Molecular-scale in-operando reconfigurable electronic hardware.

It is challenging to reconfigure devices at molecular length scales. Here we report molecular junctions based on molecular switches that toggle stably and reliably between multiple operations to reconfigure electronic devices at molecular length scales. Rather than static on/off switches that always revert to the same state, our voltage-driven molecular device dynamically switches between high and low conduction states during six consecutive proton-coupled electron transfer steps.

Unraveling the Heterogeneity of Tumor Immune Microenvironment in Hepatocellular Carcinoma by SingleCell RNA Sequencing and its Implications for Prognosis and Therapeutic Response.

Tumor immune microenvironment (TIME) has become a new hotspot in cancer research over the past few years. Tumor immune microenvironment of hepatocellular carcinoma (HCC) is especially intriguing as HCC is reported to be highly heterogeneous by previous genomic and cytological studies. It is also closely related to patient prognosis and therapeutic outcome.

Manipulating Electron-Phonon Coupling for Efficient Tin Halide Perovskite Blue LEDs.

Low-dimensional perovskites have opened up a new frontier in light-emitting diodes (LED) due to their excellent properties. However, concerns regarding the potential toxicity of Pb limited their commercial development. Sn-based perovskites are regarded as a promising candidate to replace Pb-based counterparts, while they generally exhibit strong electron-phonon coupling and consequently blue emission quenching at room temperature (RT), thus the Sn-based perovskite blue LED devices have not yet been reported.

Development and validation of the self-report symptom inventory of immune-related adverse events in patients with lung cancer.

Objective: This study aims to develop and validate the Self-Report Symptom Inventory of immune-related Adverse Events in Patients with Lung Cancer (SRSI-irAEs-LC) to allow for systematic assessment of symptomatic irAEs in patients with lung cancer treated with programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs).

Methods: A sequential two-phase mixed-methods study was conducted. In phase I, a draft version of the SRSI-irAEs-LC was constructed through item generation and draft inventory construction.

Design of an intelligent wearable device for real-time cattle health monitoring.

In the realm of precision cattle health monitoring, this paper introduces the development and evaluation of a novel wearable continuous health monitoring device designed for cattle. The device integrates a sustainable solar-powered module, real-time signal acquisition and processing, and a storage module within an animal ergonomically designed curved casing for non-invasive cattle health monitoring. The curvature of the casing is tailored to better fit the contours of the cattle's neck, significantly enhancing signal accuracy, particularly in temperature signal acquisition.

HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state.

HIV-1 infection is initiated by the interaction between the gp120 subunit in the envelope (Env) trimer and the cellular receptor CD4 on host cells. This interaction induces substantial structural rearrangement of the Env trimer. Currently, static structural information for prefusion-closed trimers, CD4-bound prefusion-open trimers, and various antibody-bound trimers is available.

An Inflammation-Related lncRNA Signature for Prognostic Prediction in Colorectal Cancer.

Background: Colorectal cancer (CRC) represents a commonly diagnosed malignancy affecting the digestive system. Mounting evidence shows long noncoding RNAs (lncRNAs) contribute to carcinogenesis. However, inflammation-related lncRNAs (IRLs) regulating CRC are poorly defined.

Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice.

Inflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model. Wild-type (WT) and TLR3-knockout (TLR3) mice received azoxymethane (AOM) 12.

The Diagnostic Efficacy of Rapid Urine Sediment Fluorescence Staining in Urinary Tract Infections: An Exploratory Study.

Objective: To investigate rapid and early diagnostic approaches for urinary tract infections (UTIs).

Methods: Coincidence rates, sensitivities, and specificities of fungal fluorescence staining for fungal detection were calculated. Additionally, the positive rate of cellular fluorescence staining was compared with bacterial urine culture, with a focus on the increasing correlation between fluorescently stained bacteria proportions and the concordance between methods.

Differential metabolic profiles of pigment constituents affecting leaf color in different albino tea resources.

Albino tea cultivars with distinct leaf colors have rarely been used to explore the metabolic mechanism of leaf color formation. Carotenoids and chlorophyll are primary pigments affecting leaf color with differential metabolic mechanisms in albino tea resources. TEM analysis showed that in albino stage, much less chloroplasts with abnormal structure were observed in white and yellow tea leaves, which corresponded to the significant reduction of total chlorophyll, Chl a and Chl b, and increase of Chl a/b, resulting in tea leaves to lose their green color.

Transcriptome comparison revealed the difference in subcutaneous fat metabolism of Qinghai yak under different feeding conditions.

In order to explore the differences in subcutaneous fat metabolism and pathway information in yaks under different feeding conditions, this experiment used Illumina high-throughput sequencing technology to sequence the transcriptome of subcutaneous fat tissues of yaks under different feeding conditions and analyzed them bioinformatically. 9 naturally grazed yaks at 18 months of age were randomly divided into 3 groups, one group (G18_SF) was slaughtered, one group (G24_SF) continued to graze until 24 months of age was slaughtered, and one group (F24_SF) was housed until 24 months of age was slaughtered, and subcutaneous fat tissue was collected from the back of the yaks. A total of 15,261 expressed genes were identified in the nine samples, with 13,959 coexpressed genes and 533 differential expressed genes (DEGs), G18_SF vs F24_SF 133 DEGs, G18_SF vs G24_SF 469 DEGs, F24_SF vs G24_SF 5 DEGs.

Substrate-induced hybridization of plasmon modes in the composite nanostructure of nanodisk array/thin film for spectrum modulation.

Hybridization coupling among plasmon modes is an effective approach to manipulate near-field properties thus optical spectral shapes of plasmonic nanostructures. Generally, mode hybridization coupling is achieved by modifying the topography and dimensions of nanostructures themselves, with few concerns about substrate-induced manipulation. Herein, we propose a composite nanostructure consisting of a gold (Au) nanodisk array and a thin Au film supported by a dielectric substrate.

Noninvasive inset-integrated meta-atom for achieving single-layer metasurface simultaneously with coded microwave reflectivity and digitalized infrared emissivity.

With the rapid improvement of equipment integration technology, multi-spectrum detectors are integrated into compact volumes and widely used for object detection. Confront with this challenge, it is essential to propose a strategy to design a single-layer metasurface with multi-spectrum responses in microwave and infrared ranges. In this work, we proposed a method of designing meta-atoms, which is capable of achieving functional electromagnetic response at microwave and infrared individually.