Publications by authors named "Han Xuan"

Rationale: Critical illness threatens millions of lives annually. Electronic health record (EHR) data are a source of granular information that could generate crucial insights into the nature and optimal treatment of critical illness.

Objectives: Overcome the data management, security, and standardization barriers to large-scale critical illness EHR studies.

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Aiming at the difficult problem of component information analysis of mixed dielectric spectra, the component information characteristics of mixed dielectric spectra are investigated by one-dimensional convolutional neural network, and the component analysis of mixed media is realised. First, the mixed dielectric spectra of water, ethanol and isopropoxyethano (iso) with different volume ratios were obtained by experimental measurements, and the singular spectrum analysis (SSA) method was applied to denoise the raw data, which provides a new data processing method for the effective analysis of dielectric spectra. Then, Utilizing the linear mixing model, we systematically obtained the dielectric spectra of binary mixtures of pure water and isopropoxyethanol with diverse ratios, along with those of multi-component mixtures integrating water, ethanol, and isopropoxyethanol at various proportion settings.

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Background: Malignant melanoma (MM) is a highly aggressive cancer. Different subtypes have different sensitivities to immunotherapy and lack peripheral blood markers. Few studies have examined the role of inflammatory markers in predicting the overall survival (OS) in stage IV acral melanoma (AM) and cutaneous melanoma (CM) patients receiving immunotherapy.

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Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we showed that pathological factors, including neuronal degeneration caused by seizures, caspase-3-induced neuronal apoptosis, neuronal debris, and β-amyloid, induced "on-demand" GPNMB expression in hippocampal microglia. Genetic ablation of GPNMB did not affect acute seizures but worsened chronic epileptogenesis.

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In the pathological progression of glaucoma, damage to the ocular nerves and associated tissue alterations can induce a systemic immune response, leading to the activation of various immune cells such as T cells, B cells, and macrophages. This complex process has the potential to intensify the clinical manifestations of glaucoma. Utilising Mendelian randomisation methods to identify the types and quantities of activated immune cells in different glaucoma-related lesions could provide robust evidence for the development of novel immunomodulators and immunosuppressants tailored to specific types of glaucoma, thereby facilitating personalised treatment strategies.

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Background: Potassium-competitive acid blocker (P-CAB)-based therapies are emerging as promising alternatives for eradicating infection. However, the comparative efficacy of P-CAB-based therapy versus proton-pump inhibitor (PPI)-based therapy in treating infection remains uncertain.

Objectives: This meta-analysis evaluated the efficacy and safety of P-CAB-based therapies, including Vonoprazan (VPZ) and Tegoprazan (TPZ), compared to PPI-based therapies for infection.

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Colorectal cancer, characterized by its high incidence, concealed early symptoms, and poor prognosis at advanced stages, ranks as the third leading cause of cancer-related deaths worldwide. (AM) refers to the dried roots of (Fisch.) Bge.

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Aim: To characterize the differences of dynamic changes for absolute lymphocyte count (ALC) among esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (nCRT) with or without pembrolizumab, as well as to investigate the clinical and lymphocyte-related organs dosimetric parameters that would impact ALC nadir during nCRT.

Materials And Methods: A total of 216 ESCC patients who received nCRT (with pembrolizumab 144; without pembrolizumab: 72) were identified from a prospective cohort. Weekly and 1-month post-nCRT ALC were identified.

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Despite the growing interest in mirror-image l-oligonucleotides, both as a robust nucleic acid analogue and as an artificial genetic polymer, their broader adoption in biochemical research and medicine remains hindered by challenges associated with the synthesis of long sequences, especially for l-RNA. Herein, we present a novel strategy for assembling long l-RNAs the joining of two or more shorter fragments using cross-chiral ligase ribozymes together with new substrate activation chemistry. We show that 5'-monophosphorylated l-RNA, which is readily prepared by solid-phase synthesis, can be activated by chemical attachment of a 5'-adenosine monophosphate (AMP) or diphosphate (ADP), yielding 5'-adenosyl(di- or tri-)phosphate l-RNA.

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Although many studies have reported the relationship between female hormone intake and cardiovascular disease (CVD) development, their association has not been fully elucidated and defined, based on data from the Third National Health and Nutrition Examination Survey intending to assess the health and nutritional status of non-institutionalized children and adults in the United States. This study examined the relationship between female hormone intake and coronary artery disease (CVD) development in 38,745 women, averaging 38.10 ± 12.

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The skin is the largest organ in the human body and is made up of various cells and structures. Over time, the skin will age, which is not only influenced by internal factors, but also by external environmental factors, especially ultraviolet radiation. Aging causes immune system weakening in the elderly, which makes them more susceptible to dermatosis, such as type 2 inflammatory mediated pruritus.

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The placenta, serving as the crucial link between maternal and infant, plays a pivotal role in maintaining a healthy pregnancy. Placental dysplasia can lead to various complications, underscoring the importance of understanding trophoblast lineage development. During peri-implantation, the trophectoderm undergoes differentiation into cytotrophoblast, syncytiotrophoblast, and extravillous trophoblast.

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The non-aeration microalgal-bacteria symbiotic system has attracted great attention due to excellent pollutants removal performance and low greenhouse gas emission. This study investigated how nitrogen (N) sources (ammonia, nitrate and urea) impact biofilm formation, pollutants removal and microbial niches in a microalgal-bacterial biofilm. Results showed that functional genus and enzymes contributed to organics biodegradation and carbon fixation, N transformation and assimilation enabled efficient pollutants removal without CO emission.

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Article Synopsis
  • Chemically modified nucleotides, especially l-oligonucleotides (the synthetic form of native d-nucleic acids), are key for developing stable research tools and new therapies.
  • L-oligonucleotides are resistant to degradation by enzymes in the body, making them more durable for various biomedical applications like imaging, diagnostics, and therapeutics.
  • The text also discusses recent advancements with l-oligonucleotides and outlines challenges and potential solutions for their wider use in clinical settings.
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  • High-voltage pulsed electric field (HV-PEF) ablation is a potential new treatment for chronic obstructive pulmonary disease (COPD), but research is still in early stages and the mechanisms are unclear.
  • Rats are chosen as the primary model for these studies due to their suitability for COPD modeling and available research tools.
  • The study focused on designing specialized electrodes for HV-PEF in rats, examining various specifications to ensure safety and effectiveness, leading to simulations that support future research on this treatment's mechanisms.
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  • * A population-based study from October 2021 to March 2022 involved active surveillance, sampling, and health surveys to estimate the disease burden, revealing approximately 52,960 ARI cases, including 2,529 severe ARI (SARI) cases.
  • * The findings showed higher incidence rates of ARI in those under 50 years and SARI in those 50 and older, underlining the importance of vaccination and informing health policy decisions.
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Article Synopsis
  • Infectious diseases are a major global health issue, creating a need for accurate predictive models, which the Baidu index can enhance through real-time data.
  • Data on the keyword "fever" was collected from 255 Chinese cities to identify when influenza epidemics began and peaked, using specific statistical thresholds.
  • An optimal method for detecting epidemic starts involves monitoring when a threshold is surpassed for several days, while peak detection is best achieved through a moving average for stability and accuracy, showcasing improved disease surveillance potential.
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Ultrasound Localization Microscopy (ULM) facilitates structural and hemodynamic imaging of microvessels with a resolution of tens of micrometers. In ULM, the extraction of effective microbubble signals is crucial for image quality. Singular Value Decomposition (SVD) is currently the most prevalent method for microbubble signal extraction in ULM.

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Post-intensive care syndrome (PICS) is a clinical syndrome characterized by new or worsening changes in mental health, cognition, or physical function that persist following critical illness. The psychiatric domain of PICS encompasses new or worsened psychiatric burdens following critical illness, including post-traumatic stress disorder (PTSD), depression, and anxiety. Many of the established predisposing and precipitating factors for the psychiatric domain of PICS are commonly found in the setting of critical illness, including mechanical ventilation (MV), exposure to sedating medications, and physical restraint.

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Gelatin-based bioadhesives, especially methacrylated gelatin (GelMA), have emerged as superior alternatives to sutureless wound closure. Nowadays, their mechanical improvement and therapeutic delivery, particularly for hydrophobic antibiotics, have received ever-increasing interest. Herein, a reinforced gelatin-based hydrogel with a hydrophobic drug delivery property for skin wound treatment was reported.

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Gastric cancer is a leading cause of cancer-related deaths in China. Affecting more than 40% of the world's population, Helicobacter pylori is a major risk factor for gastric cancer. While previous clinical trials indicated that eradication of H.

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Recently, N6-methyladenosine (mA) has aroused widespread discussion in the scientific community as a mode of RNA modification. mA comprises writers, erasers, and readers, which regulates RNA production, nuclear export, and translation and is very important for human health. A large number of studies have found that the regulation of mA is closely related to the occurrence and invasion of tumors, while the homeostasis and function of the tumor microenvironment (TME) determine the occurrence and development of tumors to some extent.

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To investigate the clinical features, imaging findings, surgical methods, diagnostic and treatment experience of spontaneous cerebrospinal fluid otorrhoea. The clinical data of 11 patients with spontaneous cerebrospinal fluid otorrhoea treated surgically at our hospital from May 2018 to May 2023 were retrospectively analyzed. The medical data included medical history, imaging data, leak location, surgical repair method, treatment effect and postoperative follow-up.

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Article Synopsis
  • The study discusses how artificial intelligence (AI) and big data can enhance monitoring and warning systems for respiratory diseases like influenza and COVID-19, highlighting their potential to improve public health responses.
  • Analyzing data from 2020 to 2023, three methods (ADTM, MLSM, MLUM) were evaluated for issuing disease warnings, showing different levels of sensitivity and specificity in their results.
  • The findings suggest that while machine learning methods showed promise, particularly in sensitivity and timeliness of warnings, there is a need for further validation and integration of these models with various data sources to strengthen public health efforts.
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Introduction: This study investigated the lagged correlation between Baidu Index for influenza-related keywords and influenza-like illness percentage (ILI%) across regions in China. The aim is to establish a scientific foundation for utilizing Baidu Index as an early warning tool for influenza-like illness epidemics.

Methods: In this study, data on ILI% and Baidu Index were collected from 30 provincial-level administrative divisions (PLADs) spanning April 2014 to March 2019.

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