Solar-powered light-modulated microwave programmable metasurface for sustainable wireless communications.

Programmable metasurface holds big promise in wireless communications by virtue of its powerful capability in controlling electromagnetic waves. However, challenges exist for the programmable metasurface in achieving self-sufficient renewable energy supply and flexible and reliable multi-domain information transmissions. Here, we report a solar-powered light-modulated microwave programmable metasurface (SLMPM) by integrating a photovoltaic module to acquire information from modulated light and energy from sunlight simultaneously.

Function of Gene Response to Infection and LPS Stimulation in the Half-Smooth Tongue Sole ().

Lysosome-associated membrane glycoproteins (LAMPs), including lysosomal membrane protein 1 (Lamp1) and lysosomal membrane protein 2 (Lamp2), are involved in phagocytosis, chaperone-mediated autophagy (CMA), and other pathways that interact with lysosomal activity. However, the role of Lamp2 in teleosts has not been clarified. In this study, we investigated the functions of genes during infection.

The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma.

Early-stage lung adenocarcinoma (LUAD) generally has a favorable prognosis. However, more than 30% of early-stage LUAD cases relapse within 5 years of initial treatment, even following complete removal of the primary tumor. Identification of the factors contributing to early-stage LUAD metastasis is needed to develop effective prevention and treatment strategies.

MCM8 promotes NR4A1-mediated E2F1 transcription and facilitates renal cell carcinoma through enhancing aerobic glycolysis.

Renal cell carcinoma (RCC) is a type of renal malignancy originated from the urinary tubular epithelial system. Despite its high incidence, the molecular mechanisms driving its pathogenesis remain poorly understood, limiting therapeutic advancements. This study explored the link between MCM8 and RCC progression.

Temporal impacts of diverse concentrations of pilocarpine ophthalmic solution on human accommodation.

Clinical Relevance: Accommodation is crucial for clear near vision and is predominantly affected by presbyopia. The ability to modulate accommodative function with eye drops could offer a pharmacological approach to manage presbyopia.

Background: To investigate the effects of different concentrations of pilocarpine eye drops on ocular accommodation in young volunteers.

Sophoricoside Inhibited Glioblastoma Cell Progression Through Activated AMP-Activated Protein Kinase (AMPK).

Glioblastoma (GBM) is the most common malignant primary brain tumor, with a mean survival of less than 2 years. Unique brain structures and the microenvironment, including blood-brain barriers, put great challenges on clinical drug development. Sophoricoside (Sop), an isoflavone glycoside isolated from seeds of Sophora japonica L.

Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.

Objective: To evaluate the longitudinal changes in the effective optical zone (EOZ) following hyperopic keratorefractive lenticule extraction (KLEx) and investigate factors influencing the EOZ.

Patients And Methods: This retrospective study included 27 patients who underwent hyperopic KLEx. According to the transition zone (TZ) sizes, they were divided into two groups: group A (21 eyes) with a 2.

TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1.

Pathological myocardial hypertrophy can induce heart failure with high mortality, it is necessary to explore its pathogenesis. Tripartite motif-containing 26 (TRIM26) belongs to the multidomain E3 ubiquitin ligase family. We observed increased expression of TRIM26 in the myocardium of C57BL/6 mice subjected to transverse aortic constriction (TAC) surgery and neonatal rat cardiomyocytes (NRCMs) treated with phenylephrine (PE).

Wireless microwave-to-optical conversion via programmable metasurface without DC supply.

Microwave-optical interaction and its effective utilization are vital technologies at the frontier of classical and quantum sciences for communication, sensing, and imaging. Typically, state-of-the-art microwave-to-optical converters are realized by fiber and circuit approaches with multiple processing steps, and external powers are necessary, which leads to many limitations. Here, we propose a programmable metasurface that can achieve direct and high-speed free-space microwave-to-laser conversion.

Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases.

The p38α-MK2 signaling axis plays an important role in the inflammatory response of cells. Here, we carried out a series of optimizations on CDD-450, aiming to enhance inhibition of the p38α-MK2 complex and improve pharmacokinetic properties. First, the magic F strategy was utilized to obtain compound , which displayed a 60-fold increase in tumor necrosis factor α inhibition and a 600-fold increase in interleukin-6 inhibition.

A novel DNA damage-related gene index for predicting prognosis in gastric cancer.

Gastric cancer is one of the major cancers with high cancer mortality and shows significant heterogeneity. The development of precise prognostic models is crucial for advancing treatment strategies. Recognizing the pivotal role of DNA damage in tumor progression, we conducted a consensus clustering analysis of DNA damage-related genes to categorize gastric cancer patients from the TCGA clinical cohort into distinct subtypes.

The SUMO (Singly Unoccupied Molecular Orbital)-LUMO (Lowest Unoccupied Molecular Orbital) Inversion Radicals.

Herein, SUMO-LUMO inversion (SLI) radicals - were designed by the combination of the tris(2,4,6-trichlorophenyl)methyl (TTM) radical and pyridinium derivatives (electron-withdrawing groups) for the first time. The energy of the LUMO lies below that of the SUMO, which deviated from the Aufbau principle as an alternative electronic configuration beyond the well-established SOMO-HOMO inversed system. Thus, for SLI radicals, the injection of one extra electron preferred to occupy the LUMO rather than the SUMO, giving diradicals, one of which had been fully confirmed by single crystal analysis, VT-NMR and VT-EPR experiments, as well as DFT calculations.

Activating Lattice Oxygen by Electrochemical De-Lithiation for Efficient Benzyl Alcohol Oxidation.

Electrocatalytic benzyl alcohol oxidation reaction (EBOR) is a feasible way to produce high-value-added benzaldehyde and benzoic acid. However, the performance of catalyst usually suffers from the high energy barrier for the O─O bonding step resulting in sluggish process. Herein, lattice oxygen activation strategy is proposed by the electrochemical de-lithiation of LiNiO to catalyze the EBOR through direct O─O bonding to significantly enhance the EBOR performance.

Efficient organic solar cells with benzo[]phenazine-core acceptors: insights into the effects of halogenation.

A series of new small-molecule acceptors-NA9, NA10, and NA11-based on benzo[]phenazine are synthesized. The chlorinated NA10 and brominated NA11 exhibit improved molecular packing and enhanced charge transport, resulting in higher power conversion efficiencies (PCEs) of 15.65% and 16.

Construction of directional electron transfer from Pt to MoO in macroporous structure for efficient hydrogen oxidation.

Hydrogen oxidation reaction (HOR) as the anode reaction in proton exchange membrane fuel cell, usually suffers from the high loading of platinum (Pt) and subsequent CO poisoning especially by using industrial crude hydrogen as fuel. In this work, we propose a directional electron transfer route from Pt to MoO in the macroporous structure to significantly enhance the HOR activity as well as the CO tolerance, which is constructed by interface engineering and defect strategy to anchor highly dispersed Pt nanoparticles onto the three-dimensional MoO-C framework. The optimized 2Pt-MoO-C with 1.

Discussion of Emotions Among Newly Diagnosed Non-Hispanic White and Chinese American Patients With Breast Cancer and Their Oncologists.

This qualitative study analyzed how Chinese American (CA) and non-Hispanic White (NHW) breast cancer patients and their oncologists communicated about patients' emotional concerns. Data included twenty-four recordings of clinical encounters between oncologists and four CA and eight NHW women with a new breast cancer diagnosis between 2013 and 2015. Using an interactional sociolinguistics approach to discourse analysis, we examined how CA and NHW patients and their oncologists initiated conversations about patients' emotions.

Synchronously Mature Intersex Japanese Flounder (): A Rare Case.

Japanese flounder is usually gonochoristic, with gonads that are either testes or ovaries. Here, we report an unusual case of hermaphroditism in Japanese flounder captured from the Bohai Sea. In the intersex flounder, the membrane of the upper ovary was closely connected to the abdominal muscles and internal organs, and the eggs filled the entire abdomen.

Intelligent Transmissive Microwave Metasurface with Optical Sensing and Transparency.

Transmissive metasurfaces are essentially conducive to stealth, absorbers, and communications. However, most of the current schemes only allow microwave to transmit and generally adopt multilayer structures or thick dielectric substrates to improve the electromagnetic performance, restricting optical transmission and conformal application. In addition, most metasurfaces still require metal wires and external power suppliers for programmability.

Seven-year refractive outcomes comparing small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis for myopia and myopic astigmatism.

This study aimed to compare the seven-year refractive outcomes of small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for correction of myopia and myopic astigmatism. This retrospective cohort study included 97 eyes of 53 patients who had undergone SMILE or FS-LASIK for myopia seven years prior. Measured parameters included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and manifest refraction.

Corneal Epithelial Remodeling After Hyperopic SMILE: A 4-Year Study.

Purpose: The purpose of this study was to investigate dynamic changes in corneal epithelial thickness (ET) after hyperopic small incision lenticule extraction (SMILE).

Methods: This observational study included 18 eyes of 16 patients who were scheduled for hyperopic SMILE. High-resolution spectral-domain optical coherence tomography and a custom image segmentation algorithm were applied to measure corneal dynamic ET over a central 6 mm area.

A genetic investigation in five Chinese families with keratoconus.

Background: This study investigated the genetic characteristics of five Chinese families with keratoconus (KC).

Methods: In the five families affected by KC, medical records, clinical observations, and blood samples were collected from all individuals. All KC family members ( = 20) underwent both whole exome sequencing of genomic DNA and Sanger sequencing to confirm the variants.