Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment.

Consumer-grade mobile devices are used by billions worldwide. Their ubiquity provides opportunities to robustly capture everyday cognition. 'Intuition' was a remote observational study that enrolled 23,004 US adults, collecting 24 months of longitudinal multimodal data via their iPhones and Apple Watches using a custom research application that captured routine device use, self-reported health information and cognitive assessments.

A new ultrasound-guided surgical technique to fix acute tibial posterior cruciate ligament avulsion fracture.

Purpose: This study aims to describe a novel minimally invasive technique for the treatment of acute tibial posterior cruciate ligament (PCL) avulsion fracture.

Methods: This retrospective study included seven patients who underwent ultrasound-guided fixation for acute PCL tibial avulsion fractures by using an adjustable-loop device between January 2021 and January 2023. Before the surgery, the maximum diameter, area and displacement distance of the fragments were measured using computed tomography examination.

Insights into Phylogeny, Taxonomy, Origins and Evolution of and , Based on Comparative Chloroplast Genome Analysis.

Hawthorns ( L.) are widely distributed and well known for their medicinal properties and health benefits. Nevertheless, the phylogenetic relationships among native to China remain unclear.

Corrigendum: Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress.

[This corrects the article DOI: 10.3389/fphar.2024.

Evaluation of the efficacy and safety of a novel xanthine oxidase inhibitor, tigulixostat, in gout patients with hyperuricemia: Design of the EURELIA 1 and EURELIA 2 studies.

Background: Gout is a chronic disease of monosodium urate crystal deposition caused by elevated serum urate (SU). Gout may progress from acute episodic attacks to a disabling chronic deforming arthropathy. Allopurinol and febuxostat are the most widely prescribed urate-lowering drugs, however, these agents have potential adverse events and are seldom titrated to achieve a target SU level.

Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning.

Background: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in the death of neuronal cells during SCI.

Long-term efficacy and safety of endoscopic surgery versus small bone window craniotomy for spontaneous supratentorial intracerebral hemorrhage: a meta-analysis and trial sequential analysis.

Background And Aims: Endoscopic surgery (ES) and small bone window craniotomy (SBWC) are commonly used methods for hematoma removal in cases of intracerebral hemorrhage (ICH). However, their long-term efficacy and safety remain uncertain.

Methods: A systematic search was performed in the PubMed, Embase, and Cochrane Library databases from inception to June 30, 2024.

Geometry-symmetry-free and material-symmetry-guaranteed polariton-induced transparency.

Plasmon-induced transparency is a classical analogue of electromagnetically induced transparency (EIT). However, its realization and control primarily rely on geometry engineering rather than tuning plasmon polaritons (PPs) themselves, due to their relatively poor tunability. Recently discovered polariton modes in low-symmetry materials exhibit volume-confined field distributions, thickness-dependent dispersions, and in-plane anisotropy, offering possibilities for the realization and manipulation of polariton-induced transparency (PIT).

The bacterial composition signatures of perianal abscess and origin of infecting microbes.

Background: Perianal abscess is a common anal condition primarily caused by bacterial infections, yet the precise origins of these infecting bacteria remain unclear. Understanding the distinct microbial signatures associated with periaabscesses is crucial for provide fresh ideas for disease prevention.

Materials And Methods: Samples of anal skin, feces, and abscesses were collected from a cohort of 75 patients diagnosed with perianal abscesses.

A Review of Potentially Toxic Elements in Sediment, Water, and Aquatic Species from the River Ecosystems.

There is concern over potential toxic elements (PTEs) impacting river ecosystems due to human and industrial activities. The river's water, sediment, and aquatic life are all severely affected by the release of chemical and urban waste. PTE concentrations in sediment, water, and aquatic species from river ecosystems are reported in this review.

A SERS/colorimetric biosensor based on AuNSs@Ag core-shell Prussian blue nanozyme for non-interference and rapid detection of Staphylococcus aureus in milk.

A AuNSs@PB@Ag-Apt surface-enhanced Raman scattering (SERS) probe has been developed by embedding Prussian blue (PB) between Au core and Ag shell. The PB SERS probe illustrates strong SERS activity in the Raman silent region of 2070 cm, and has a zero background signal, ensuring high sensitivity for the detection of Staphylococcus aureus (S. aureus).

Comparison of anterior chamber depth measured by three different anterior segment analysis systems.

Purpose: This study aims to compare and evaluate the correlation and agreement among three distinct anterior segment analysis systems in measuring anterior chamber depth (ACD) in healthy myopic individuals.

Methods: Myopic patients who underwent preoperative assessments at our hospital's refractive surgery department from January 2021 to December 2023 were included in this investigation. ACD was measured using three anterior segment analysis systems: Pentacam, Sirius, and IOLMaster 700.

Media multitasking enhances individuals' anticipatory brain functions.

Media multitasking has become pervasive in our daily lives, yet its impact on cognitive abilities remains contentious, with more evidence supporting adverse effects (scattered attention hypothesis) than benefits (trained attention hypothesis). Recent studies have increasingly focused on the training effects of behavioral training on anticipatory brain functions, which involve cognitive and motor preparation before stimulus onset, assessed using event-related potentials (ERPs). This study investigated whether media multitasking enhances anticipatory brain functions and how task difficulty influences this relationship.

Relationship between cyberbullying victimization and depression in middle school students: the mediating role of coping strategies and the moderating role of face consciousness.

Background: The more rapid adoption of the Internet in education settings has raised concerns about its impact on adolescents who may suffer from cyberbullying victimization. As a negative life experience, cyberbullying victimization can adversely affect adolescents' mental health. Particularly, it can lead to more adolescents developing depression.

Elevated Astrocytic NFAT5 of the hippocampus increases epilepsy susceptibility in hypoxic-ischemic mice.

Objective: Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal mortality, resulting in brain injury and persistent seizures that can last into the late neonatal period and beyond. Effective treatments and interventions for infants affected by hypoxia-ischemia remain lacking. Clinical investigations have indicated an elevation of nuclear factor of activated T cells 5 (NFAT5) in whole blood from umbilical cords of severely affected HIBD infants with epilepsy.

Knockout of hexokinase 2 regulates mitochondrial dysfunction and activates the NLRP3 signal pathway in the rumen epithelial cells of dairy cows.

Hexokinase 2 (HK2) plays a vital role in mitochondrial homeostasis; however, the molecular mechanisms underlying its involvement in high-concentrate diet-induced damage in the ruminal epithelium of dairy cows are poorly understood. This study aimed to explore the regulatory role of HK2 in mitochondrial function and responses to inflammation in the rumen of dairy cows fed a high-concentrate diet. Our results showed that, compared with a low-concentrate (LC) diet, feeding a high-concentrate (HC) diet increased oxidative stress and reduced relative antioxidant gene expression levels and enzyme activities in the ruminal epithelium.

Establishment of a chronic biliary disease mouse model with cholecystoduodenal anastomosis for intestinal microbiome preservation.

Background: Chronic biliary disease, including cholangitis and cholecystitis, is attributed to ascending infection by intestinal bacteria. Development of a mouse model for bile duct inflammation is imperative for the advancement of novel therapeutic approaches. Current models fail to replicate the harmful bacterial influx to the biliary tract observed in humans and spread of inflammation to the liver.

Comparative Evaluation of Clinical-MRI, Radiomics, and Integrated Nomogram Models for Preoperative Prediction of Placenta Accreta Spectrum.

Rationale And Objectives: The escalating incidence of placental accreta spectrum (PAS), a pregnancy complication, underscores the need for accurate prenatal diagnosis to guide optimal management strategies. This study aims to develop, validate, and compare various prenatal PAS prediction models integrating clinical data, MRI signs, and radiomics signatures.

Materials And Methods: A cohort comprising 111 patients (72 with PAS and 39 without, denoted as N-PAS) served as the training set, while another 47 patients (33 PAS and 14 N-PAS) constituted the validation set.

Variability of quality-of-life measurements and reporting in randomised controlled trials of pancreatic cancer: a systematic review.

Objectives: This systematic review aims to evaluate the methodology used in pancreatic cancer (PC) randomised controlled trials (RCTs) measuring quality of life (QOL) and focuses on the type, frequency, survey compliance and duration of these assessments.

Design: Systematic review of PC RCTs measuring QOL.

Data Sources: A search of PubMed.

Endoscopic far-lateral supracerebellar infratentorial approach for resection of clival chordoma: case report.

Introduction: The surgery of clival chordoma remains one of the most formidable challenges for neurosurgeons because of its location at great depth in the cranium and proximity to critical neurovascular structures. Here, we describe the technique and feasibility of the purely endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA) for resection of an intradural clival chordoma.

Case Description: A 68-year-old women presented with sudden ptosis on the left side for two weeks.

Antibiotic resistance genes transfer risk: Contributions from soil erosion and sedimentation activities, agricultural cycles, and soil chemical contamination.

The transfer of antibiotic resistance genes (ARGs) pose environmental risks that are influenced by soil activity and pollution. Soil erosion and sedimentation accelerate degradation and migration, thereby affecting soil distribution and contamination. This study quantified the vertical and horizontal transfer capabilities of ARGs and simulated soil environments under various scenarios, such as erosion, agricultural cycles, and chemical pollution.

A Novel Aerial-Aquatic Unmanned Vehicle Using Flapping Wings for Underwater Propulsion.

Aerial-aquatic unmanned vehicles are a combination of unmanned aerial vehicles and unmanned submersibles, capable of conducting patrols in both the air and underwater domains. This article introduces a novel aerial-aquatic unmanned vehicle that integrates fixed-wing configuration and flapping-wing configuration. In order to improve the low efficiency of the classic diagonal motion trajectory, this paper proposed an improved diagonal motion trajectory based on joint optimization of the stroke angle and angle of attack curve.