KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.

Glioblastoma (GBM) is highly invasive and lethal. The failure to cure GBM highlights the necessity of developing more effective targeted therapeutic strategies. KIF15 is a motor protein to be involved in cell mitosis promotion, cell structure assembly and cell signal transduction.

Triggering Reversible Intercalation-Conversion Combined Chemistry for High-Energy-Density Lithium Battery Cathodes.

Combining intercalation and conversion reactions maximizes the utilization of redox-active elements in electrodes, providing a means for overcoming the current capacity ceiling. However, integrating both mechanisms within a single electrode material presents significant challenges owing to their contrasting structural requirements. Intercalation requires a well-defined host structure for efficient lithium-ion diffusion, whereas conversion reactions entail structural reorganization, which can undermine intercalation capabilities.

Targeting TLR4 and regulating the Keap1/Nrf2 pathway with andrographolide to suppress inflammation and ferroptosis in LPS-induced acute lung injury.

Acute lung injury (ALI) is a severe inflammatory condition with a high mortality rate, often precipitated by sepsis. The pathophysiology of ALI involves complex mechanisms, including inflammation, oxidative stress, and ferroptosis, a novel form of regulated cell death. This study explores the therapeutic potential of andrographolide (AG), a bioactive compound derived from Andrographis, in mitigating Lipopolysaccharide (LPS)-induced inflammation and ferroptosis.

Selective adsorption of arsenic by water treatment residuals cross-linked chitosan in co-existing oxyanions competition system.

Selective adsorption of arsenic in co-existing oxyanions competition systems remains a significant challenge in water treatment due to the limitations of adsorbent materials that often overlook competitive adsorption, resulting in an overestimation of their actual purification potential for target contaminants. In this study, a novel hydrogel bead adsorbent, composed of water treatment residuals (WTRs) and chitosan (Chi), was developed to selectively remove arsenic, while minimizing the interference from phosphate, which is the strongest and most representative competitor in multi-oxyanion systems. The WTRs-Chi beads (WCB) adsorbents were optimized by adjusting the ratios of WTRs:Chi, with characterization results indicating that increased WTR doping improved the degree of crosslinking and the formation of bidentate complexes with enhanced electrostatic selectivity.

Microplastics colonized by Hafnia paralvei through biofilm formation regulated by c-di-GMP and cAMP promote its spread in water.

Microplastics (MPs) colonized by pathogens pose significant risks to the environment and health of animals and humans, however, the strategies for pathogens colonization in MPs and the effects of its colonization on spread of pathogens have not been fully characterized. Here, we investigated the biofilm formation mechanism regulated by c-di-GMP in Hafnia paralvei Z11, and determined the effect of MPs colonized by H. paralvei Z11 on the spread of strain Z11.

Volume and Permeability of White Matter Hyperintensity on Cognition: A DCE Imaging Study of an Older Cohort With and Without Cognitive Impairment.

Background: The impact of blood-brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear.

Purpose: To investigate the relationship between WMH volume, permeability, clinical factors, and cognition in older individuals across the cognitive spectrum.

Study Type: Prospective, cross-sectional.

Efficiency bounds for bipartite information-thermodynamic systems.

In this paper, we introduce an approach to derive a lower bound for the entropy production rate of a subsystem by utilizing the Cauchy-Schwarz inequality. It extends to establishing comprehensive upper and lower bounds for the efficiency of two subsystems. These bounds are applicable to a wide range of Markovian stochastic processes, which enhances the accuracy in depicting the range of energy conversion efficiency between subsystems.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

Latent factors affecting safer injection practices that can reduce infections and how education can improve them.

Background: The incidence of healthcare-associated infections, particularly injection-related infections, can increase patient comorbidities even in countries with adequate medical resources. Although there are clear guidelines for injection practices to prevent infections, their application in clinical settings is insufficient. Therefore, the objective of this study was to identify factors affecting injection practices associated with reduced infections by conducting surveys targeting practicing healthcare providers involved in administering injections at each healthcare organization and performing data analysis.

A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation.

The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity effect independent of its canonical mitoUPR function.

Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence.

Objectives: The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between circulating RAC1 and SSNS.

Methods: The association between circulating RAC1 and SSNS at both gene expression and proteomic levels was investigated using Mendelian randomization analysis, and further validated by single-cell RNA-sequencing, proteomic analysis, and experimental studies.

[Corrigendum] MicroRNA‑378 enhances migration and invasion in cervical cancer by directly targeting autophagy‑related protein 12.

Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, for the cell migration and invasion assay experiments shown in Fig. 2 on p. 6322, the 'HeLa/miR‑378 inhibitor' panels in Fig.

Plasma exchange and intravenous immunoglobulin prolonged the survival of a porcine kidney xenograft in a sensitized, deceased human recipient.

Background: The primary limitation to kidney transplantation is organ shortage. Recent progress in gene editing and immunosuppressive regimens has made xenotransplantation with porcine organs a possibility. However, evidence in pig-to-human xenotransplantation remains scarce, and antibody-mediated rejection (AMR) is a major obstacle to clinical applications of xenotransplantation.

Identifying Primary Proximal Caries Lesions in Pediatric Patients From Bitewing Radiographs Using Artificial Intelligence.

To develop a no-code artificial intelligence (AI) model capable of identifying primary proximal surface caries using bitewings among pediatric patients. One hundred bitewing radiographs acquired at pediatric dental clinics were anonymized and reviewed. The inclusion criteria encompassed bitewing radiographs of adequate diagnostic quality of primary and mixed-dentition stages.

Highly efficient dip catalysts using bacterial cellulose impregnated with self-crosslinked glycol chitosan and silver nanoparticles for 4-nitrophenol reduction.

The application of environmentally friendly and sustainable catalysts requires efficient and safe preparation methods using cheap and renewable materials. Although many metal nanoparticles (NPs) have low colloidal stability, they are still very effective as catalysts. Using a straightforward method, we developed a bacterial cellulose-glycol chitosan-silver (BC-GCS-Ag) nanocomposite, by introducing both AgNPs and self-crosslinked GCS within the BC network.