Metabolic Status and Hypertension: The Impact of Insulin Resistance-Related Indices on Blood Pressure Regulation and Hypertension Risk.

Background: Diabetes is closely related to hypertension, and insulin resistance-related indices are novel metrics used to evaluate the risk of diabetes and cardiovascular diseases. This study aims to explore the relationships between the TyG index, METS-IR, TG/HDL-C, and HOMA-IR with hypertension.

Methods: Data from the NHANES spanning ten consecutive survey cycles from 1998 to 2018 were utilized, focusing on adults with complete blood pressure data and comprehensive information for calculating the TyG index, METS-IR, TG/HDL-C, and HOMA-IR.

Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity.

Chromothripsis, a hallmark of cancer, is characterized by extensive and localized DNA rearrangements involving one or a few chromosomes. However, its genome-wide frequency and characteristics in urothelial carcinoma (UC) remain largely unknown. Here, by analyzing single-regional and multi-regional whole-genome sequencing (WGS), we present the chromothripsis blueprint in 488 UC patients.

Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma.

Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism.

Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol.

Background: Kangaroo mother care (KMC) is a care of preterm and low birthweight infants carried skin-to-skin contact with the mother's chest and breastfeeding when possible. KMC has been proven to reduce mortality and morbidity in these infants. However, research on KMC has been limited by significant variability and inconsistency in reported outcomes across studies.

Genomic and Gut Microbiome Evaluations of Growth and Feed Efficiency Traits in Broilers.

In this study, we combined genomic and gut microbiome data to evaluate 13 economically important growth and feed efficiency traits in 407 Dahen broilers, including body weight (BW) at four, six, nine, and ten weeks of age (BW4, BW6, BW9, and BW10), as well as the average daily gain (ADG6, ADG9, and ADG10), feed conversion ratio (FCR6, FCR9, and FCR10), and residual feed intake (RFI6, RFI9, and RFI10) for the three growing ages. The highest ADG and lowest FCR were observed at nine and six weeks of age, respectively. We obtained 47,872 high-quality genomic single-nucleotide polymorphisms (SNPs) by sequencing the genomes and 702 amplicon sequence variants (ASVs) of the gut microbiome by sequencing the 16S rRNA gene, both of which were used for analyses of linear mixed models.

Hypoxia-Preconditioned Adipose Stem Cell Exosomes Promote Adipose Graft Vascular Regeneration via miRNA-126.

Background And Objective: Adipose-derived mesenchymal stem cell-derived extracellular vesicles (ASCs-Exos) possess angiogenic potential, which can enhance the retention rate of fat grafts. Hypoxic preconditioning can augment their functionality. However, the optimal conditions for hypoxic preconditioning and the specific mechanisms by which it exerts its effects are not well defined.

Mitophagy in ischemic heart disease: molecular mechanisms and clinical management.

The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease.

Soybean bioactive peptide supplementation improves gut health and metabolism in broiler chickens.

This study aimed to investigate the effects of soybean bioactive peptide (SBP) on the growth performance and intestinal health of yellow-feathered broilers and to further elucidate the regulatory mechanisms of intestinal health using multi-omics analysis. A total of 320 1-day-old yellow-feathered broilers were randomly divided into two groups, with 10 replicates per group and 16 birds per replicate. Broilers in the control group received the basal diet, and those in the experimental group (SBPG) received the basal diet with 0.

Characterization of a maltononaose-producing amylopullulanase from Bacillus aryabhattai W310.

The recombinated amylopullulanase of PulW310B, pullulanase from Bacillus aryabhattai W310, was characterized. Sequence analysis of PulW310B showed that PulW310B has type I pullulanase structures including its typical region and the conserved regions of glycoside hydrolase family 13. Moreover, PulW310B was predicted to has typical domains of pullulanase and SSF51445 belonging to tansglycosidase.

Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health.

Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing and bioinformatics, the accuracy of eccDNAs detection has significantly improved. This advancement has consequently enhanced the feasibility of exploring the biological characteristics and functions of eccDNAs.

Etiology and clinical features of children with bronchiectasis-Insight from Chinese experience.

Bronchiectasis is a clinical syndrome characterized by cough, sputum production, and the presence of abnormal thickening and dilation of the bronchial wall on imaging. There has been a remarkable resurgence in incidence and prevalence during the past 20 years. There was few data from children.

Cold-Induced Browning: A Novel Method to Improve the Retention Rate of Fat Graft.

Background: Autologous fat grafting is frequently used to heal soft-tissue defects. The key restriction that must be addressed is the poor transplant retention rate. Growing evidence has demonstrated that the browning of white adipose tissue enhances the survival of fat grafts.

Semantic Scene Completion in Autonomous Driving: A Two-Stream Multi-Vehicle Collaboration Approach.

Vehicle-to-vehicle communication enables capturing sensor information from diverse perspectives, greatly aiding in semantic scene completion in autonomous driving. However, the misalignment of features between ego vehicle and cooperative vehicles leads to ambiguity problems, affecting accuracy and semantic information. In this paper, we propose a Two-Stream Multi-Vehicle collaboration approach (TSMV), which divides the features of collaborative vehicles into two streams and regresses interactively.

Preparation and Evaluation of a Combination of Chelating Agents for the Removal of Inhaled Uranium.

Inhalation of aerosolized uranium is recognized as a principal mode of exposure, posing significant risks of damage to the lungs, kidneys, and other vital organs. To enhance nuclide elimination from the body, chelating agents are employed; however, single-component chelators often exhibit limited spectral activity and low effectiveness, resulting in toxicologically relevant concentrations. We have developed a composite chelating agent composed of 3,4,3-Li(1,2-HOPO), DFP, and HEDP in optimized ratios, demonstrating marked improvements in eliminating inhaled uranium.

RNA-Seq Transcriptomics and iTRAQ Proteomics Analysis Reveal the Dwarfing Mechanism of Blue Fescue ().

Blue fescue is a widely used ornamental grass because of its strong ecological adaptability. To maintain the optimal ornamental plant shape, blue fescue requires many nutrients and labor. Using dwarf varieties with slow growth is an effective way to fulfill these requirements.

Organocatalytic Enantioselective Synthesis of [5.7]-Fused ε-Sultam ,-Heterocycles via (3 + 2)-Annulation of Seven-Membered Cyclic -Sulfonylimines with γ-Hydroxy-α,β-Unsaturated Ketones.

A highly stereoselective protocol for the (3 + 2)-annulation of biphenyl-bridged seven-membered cyclic -sulfonylimines with γ-hydroxy-α,β-unsaturated ketones was developed. The reactions afforded a wide range of chiral [5.7]-fused ε-sultams bearing N-adjacent 1,3-stereocenters in excellent yields (93-98% yields) and high enantio/diastereoselectivities (up to >99% ee, >20:1 d.

Efficacy and cost-effectiveness analysis of flexible ureteroscopic lithotripsy with TFDS in the treatment of urolithiasis.

Background: At present, there is no effective drug to remove residual stones. Total flavonoids of desmodium styracifolium (TFDS) is an innovative traditional Chinese medicine listed in 2022, which can be used to treat ureteral calculi. This study was to explore the effectiveness and economic value of TFDS in the treatment of residual stones after flexible ureteroscopic lithotripsy (FURL).

Medication-Induced Lymphomatoid Granulomatosis Presenting as a Solitary Periocular Cutaneous Lesion.

Lymphomatoid granulomatosis, a rare lymphoproliferative disorder, was previously defined by categorical pulmonary involvement with possible invasion into the skin, central nervous system, liver, and kidneys. However, recent reports have documented confirmed cases of lymphomatoid granulomatosis without lung involvement. Here, the authors describe a 70-year-old male with rheumatoid arthritis on methotrexate who presented with an ulcerating lesion on the right lower eyelid, initially suspicious for a basal cell carcinoma.

Loss of the mitochondrial protein mitoNEET in mice is associated with cognitive impairments and increased neuroinflammation.

Background: Mitochondrial dysfunction is implicated in several neurodegenerative diseases associated with memory and cognitive deficits, including Alzheimer's disease. Changes in bioenergetic function results in reactive oxygen species, oxidative damage and consequently neuroinflammation, which contributes to neuronal cell loss.

Objective: In this study, we evaluated the impact of the loss of the redox active [2Fe-2S] mitochondrial-associated protein mitoNEET (CISD1) on neuroinflammation and cognition using an age-appropriate preclinical model.

[Application of CT Radiomics in Predicting Differentiation Level of Lung Adenocarcinoma].

Objective: To investigate the value of prediction of the differentiation level in lung adenocarcinoma based on CT radiomics model.

Methods: Data from 507 patients with postoperative pathological confirmed lung adenocarcinoma and clearly defined differentiation level of lung adenocarcinoma were retrospective analyzed. The enrolled cases were divided into poorly differentiation group and moderate-to-high differentiation group based on the grading criteria.

Research on autonomous walking performance and electromechanical characteristics of mining double-track chassis.

To study the autonomous walking performance and corresponding electromechanical characteristics of unmanned mining equipment under different slopes, turning radii, and ground conditions. Firstly, the autonomous walking systems based on PID, fuzzy PID, and BP PID, in this paper, are constructed, and then the electromechanical coupling simulation is carried out to analyse autonomous walking performance and electromechanical characteristics of mining double-track chassis under different working conditions. Finally, the feasibility of the autonomous walking system based on fuzzy PID is verified by the path-tracking experiment.

calculations of vibrational fingerprints in the photoluminescence of graphene quantum dots.

We used a computational method based on (constrained) density functional theory to obtain the photoluminescence spectrum of graphene quantum dots with up to 240 carbon atoms, including the effect of multiphonons. We found that only a few phonon modes couple effectively to the excitons, namely one size- and shape-dependent global mode and two high frequency local modes. The exciton-phonon coupling decreases with increasing size for all structures and has a magnitude in the mid-range, leading to only relatively small multiphonon effects.

Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma.

Objectives: To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC).

Methods: This retrospective study enrolled 78 patients with single HCC diagnosed by postoperative pathology between January 1, 2021, and June 30, 2022. All patients underwent ultrasound and H-CEUS examination before operation.

Multi-plane imaging based on cascade spintronic terahertz emitters with curved substrates.

As a novel terahertz (THz) source, a spintronic THz emitter (STE) has become a research hot topic recently due to its ultra-broadband emission, powerful scalability, simple fabrication, and ultrawide pump-wavelength range. To optimize the performance of a STE, its spintronic heterostructure has been extensively investigated and its accessories have been also appropriately improved. In this work, a curved substrate of a STE was proposed and utilized to achieve the modulation of the THz wave front as a new degree of freedom.