Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Y10.

To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (⁻), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (), was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation with an IC of 7.

The presurgical T staging of non-small cell lung cancer: efficacy comparison of 64-MDCT and 3.0 T MRI.

Background: Lung cancer has been the main concern of the cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is reported the most common subtype of lung cancer. Initial staging of NSCLC is highly associated with the choice of treatment and prognosis of the patients.