Publications by authors named "Han Noo Ri Lee"
Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage-associated molecular patterns (DAMPs), including adenosine triphosphate (ATP), from activated and dying cells. Purinergic receptors activated by ATP have gained attention for their roles in sepsis, which can be pro- or anti-inflammatory depending on the context.
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- Elevated endothelial permeability during sepsis is linked to organ dysfunction and mortality, but the mechanisms behind this increase remain unclear.
- Previous research indicated that cell-free hemoglobin (CFH) is found at high levels in sepsis patients and can increase lung microvascular permeability.
- This study showed that CFH worsens outcomes in a mouse model of sepsis, contributing to higher mortality and inflammation while suggesting that CFH may be a potential target for treatment.
Exaggerated synaptic elimination in the prefrontal cortex (PFC) during adolescence has been suggested to contribute to the neuropathological changes of schizophrenia. Recent data indicate that microglia (MG) sculpt synapses during early postnatal development. However, it is not known if MG contribute to the structural maturation of the PFC, which has a protracted postnatal development.
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