Investigating the eye-catching effect in the entrance zone of highway tunnels through heart rate variability analysis.

Objective: This study aimed to investigate the influence of visual attraction conditions on drivers' cognitive workload and physiological responses, assessed through heart rate variability (HRV) indicators. The study examined four experimental scenarios, including a baseline condition and three visual attractions (landscape-style architecture, tip slogan, and billboard) at tunnel entrances.

Methods: HRV indicators, including RMSSD, SDNN, LF, and LF/HF ratio, were analyzed to assess cognitive workload and physiological states.

Chiral Nanostructured Ag Films for Multicarbon Products from CO Electroreduction.

The formation of multicarbon products from CO electroreduction is challenging on materials other than Cu-based catalysts. Ag has been known to be a typical metal catalyst, producing CO in CO electroreduction. The formation of C products by Ag has never been reported because the carbon-carbon (C-C) coupling is an unfavorable process due to the high reaction barrier energy of *OCCO.

Engineering Plant Metabolism for Synthesizing Amino Acid Derivatives of Animal Origin Using a Synthetic Modular Approach.

The biosynthesis of amino acid derivatives of animal origin in plants represents a promising frontier in synthetic biology, offering a sustainable and eco-friendly approach to enhancing the nutritional value of plant-based diets. This study leverages the versatile capabilities of as a transient expression system to test a synthetic modular framework for the production of creatine, carnosine, and taurine-compounds typically absent in plants but essential for human health. By designing and stacking specialized synthetic modules, we successfully redirected the plant metabolic flux toward the synthesis of these amino acid derivatives of animal origin.

Effects of 17α-methyltestosterone and letrozole on growth and gonadal development in largemouth bass ().

In order to optimize the parameters for reversing masculinization and establish the techniques for sex induction of pseudo-males and creation of all-female fry in largemouth bass (, LMB), 15-day-old LMB (1.00 ± 0.10 cm in length, 0.

Cardiomyopathy-Associated Chronic Heart Failure in Infants Aged <1 Year: A Prospective Observational Cohort Over 5 Years in Northern China.

Background: There have been few large-scale studies on the outcomes of cardiomyopathy-associated heart failure (HF) in infants aged <1 year. This study aimed to assess longitudinal echocardiographic outcomes of infants with HF secondary to cardiomyopathy who survived for >1 year.

Methods And Results: A prospective observational study following 327 infant patients up to 5 years in 2 large pediatric heart centers in Northern China between January 2010 and December 2018.

Genome-wide comparative analysis of CC1 Staphylococcus aureus between colonization and infection.

Background: Staphylococcus aureus is one of the most important bacteria in human colonization and infection. Clonal complex1 (CC1) is one of the largest and most important S. aureus CCs, and it is a predominant clone in S.

Thermal stability of sedimentary organic carbon in a large river dominated marginal sea.

The thermal stability of organic carbon (OC) in marine sediments is one of the critical factors that influences its burial efficiency in marine environments. However, the distribution patterns and influencing factors of the thermal stability of OC in marginal seas remain poorly understood. In this study, we conducted the thermal gravimetric analysis (TGA) of OC in surface sediments of the Changjiang Estuary (CE) and its adjacent East China Sea (ECS) shelf.

Development of FeO/DEX/PDA@Au(Raman reporters)@Au-MPBA nanocomposites based multi-hotspot SERS probe for ultrasensitive, reliable, and quantitative detection of glucose in sweat.

Glucose is a key biomarker of diabetes, and effective glucose monitoring methods are crucial to the prevention and management of diabetes. Therefore, in this paper, FeO/DEX/PDA@Au (Raman reporters) @Au nanocomposites were synthetized that with DTNB (5,5'-dithiobis(2-nitrobenzoic)), MMTA (2-mercapto-4-methyl-5-thiazole acetic acid), MBA (4-mercaptobenzoic acid) and 4-Mpy(4-Mercaptopyridine) were used separately as Raman reporters. FeO and PDA (Polymerized dopamine) could supply more high surface area of active sites and high SERS (Surface-Enhanced Raman Scattering) substrate, which has high stability and reproducibility.

Potential functions and mechanisms of lysine crotonylation modification (Kcr) in tumorigenesis and lymphatic metastasis of papillary thyroid cancer (PTC).

Objectives: To examine the putative functions and mechanisms of lysine crotonylation (Kcr) during the development and progression of papillary thyroid cancer (PTC).

Methods: Samples of thyroid cancer tissues were collected and subjected to liquid chromatography-tandem mass spectrometry. Crotonylated differentially expressed proteins (DEPs) and differentially expressed Kcr sites (DEKSs) were analyzed by Motif, dynamic expression model analysis (Mfuzz), subcellular localization, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, Go Ontology (GO) annotation, and protein-protein interaction analysis (PPI).

Inhibition of the NLRP3/caspase-1 cascade related pyroptosis relieved propofol-induced neuroinflammation and cognitive impairment in developing rats.

Background: Numerous preclinical studies have demonstrated that prolonged exposure to propofol (A general anaesthetics) can lead to hippocampus injury in immature brains and impact long-term learning and memory functions. Neuroinflammation plays a pivotal role in the impairment of brain function associated with early exposure to anesthetic drugs. Nevertheless, the involvement of hippocampal pyroptosis and neuroinflammation mediated by the NLRP3/caspase-1 signaling cascade in propofol-induced developmental neurotoxicity remains unclear.

High-performance ratiometric fluorescence detection and removal of tetracycline in milk based on CDs@ZSM-5:Eu.

Exploring materials with the dual functionality of detecting and removing tetracycline (TC) residues is crucial because of the environmental and health risks posed by antibiotic overuse. This study introduces a dual-emissive luminescent probe, CDs@ZSM-5:Eu, created through a solvent-free method combined with subsequent Euion exchange. The nanocomposite's blue emission, originating from carbon dots (CDs), is quenched by TC via an internal filtering effect, while an antenna effect triggers a strong red fluorescence of a TC-Euchelate.

Intermedin Alleviates Diabetic Cardiomyopathy by Up-Regulating CPT-1β through Activation of the Phosphatidyl Inositol 3 Kinase/Protein Kinase B Signaling Pathway.

Diabetic cardiomyopathy (DCM), one of the most serious long-term consequences of diabetes, is closely associated with myocardial fatty acid metabolism. Carnitine palmitoyltransferase-1β (CPT-1β) is the rate-limiting enzyme responsible for β-oxidation of long-chain fatty acids. Intermedin (IMD) is a pivotal bioactive small molecule peptide, participating in the protection of various cardiovascular diseases.

Application of Exogenous Ascorbic Acid Enhances Cold Tolerance in Tomato Seedlings through Molecular and Physiological Responses.

Ascorbic acid (AsA), an essential non-enzymatic antioxidant in plants, regulates development growth and responses to abiotic and biotic stresses. However, research on AsA's role in cold tolerance remains largely unknown. Here, our study uncovered the positive role of AsA in improving cold stress tolerance in tomato seedlings.

A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ.

Background: Circular RNAs (circRNAs) can influence a variety of biological functions and act as a significant role in the progression and recurrence of glioblastoma (GBM). However, few coding circRNAs have been discovered in cancer, and their role in GBM is still unknown. The aim of this study was to identify coding circRNAs and explore their potential roles in the progression and recurrence of GBM.

Microplastics regulate soil microbial activities: Evidence from catalase, dehydrogenase, and fluorescein diacetate hydrolase.

Soil microbiomes drive many soil processes and maintain the ecological functions of terrestrial ecosystems. Microplastics (MPs, size <5 mm) are pervasive emerging contaminants worldwide. However, how MPs affect soil microbial activity has not been well elucidated.

Bidirectional Decoupled Distillation for Heterogeneous Federated Learning.

Federated learning enables multiple devices to collaboratively train a high-performance model on the central server while keeping their data on the devices themselves. However, due to the significant variability in data distribution across devices, the aggregated global model's optimization direction may differ from that of the local models, making the clients lose their personality. To address this challenge, we propose a Bidirectional Decoupled Distillation For Heterogeneous Federated Learning (BDD-HFL) approach, which incorporates an additional private model within each local client.

The relationship between arterial partial pressure of oxygen and pressure injuries in intensive care unit patients: A multi-center cross-sectional study.

Background: Pressure injuries significantly impact patients in intensive care units and the healthcare system. Hypoxia, a major contributor to pressure injury development, can be promptly identified by monitoring arterial partial pressure of oxygen. However, the dose-response relationship between arterial partial pressure of oxygen and pressure injuries remains unclear.