Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis: A Systematic Review.

Objective: This study explored the potentially modifiable factors for depression and major depressive disorder (MDD) from the MR-Base database and further evaluated the associations between drug targets with MDD.

Methods: We analyzed two-sample of Mendelian randomization (2SMR) using genetic variant depression ( = 113,154) and MDD ( = 208,811) from Genome-Wide Association Studies (GWAS). Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 genomes.

Effect of Affective Personality Information on Face Processing: Evidence from ERPs.

This study explored the extent to which there are the neural correlates of the affective personality influence on face processing using event-related potentials (ERPs). In the learning phase, participants viewed a target individual's face (expression neutral or faint smile) paired with either negative, neutral or positive sentences describing previous typical behavior of the target. In the following EEG testing phase, participants completed gender judgments of the learned faces.

Moral-up first, immoral-down last: the time course of moral metaphors on a vertical dimension.

Many abstract bipolar concepts are usually represented by metaphors on vertical dimensions (e.g. positive-up, negative-down).

Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.

Purpose: We have developed and tested a novel conjugation of the clinically used prodrug aminolevulinic acid with 2-deoxyglucosamine as a novel probe (ALA-2DG) for fluorescence imaging and photodynamic therapy.

Procedures: ALA-2DG was successfully synthesized, and the mechanisms of probe uptake, PpIX synthesis, and photodynamic therapy efficacy were evaluated in vitro and in vivo.

Results: ALA-2DG led to PpIX synthesis in tumor cells in vitro and in tumor in vivo.