The current attitudes and practices of dentists in Australia towards composite repair: A cross-sectional survey study.

Background: Whether to replace or repair a composite restoration is controversial and varies among clinicians. This study was designed to collect information on the attitudes and practices of Australian dentists towards composite repair.

Methods: An electronic 16-item questionnaire was distributed online on Australian clinicians' dental forum with a URL address and instructions on completing the survey.

Capmatinib in MET exon 14-mutated non-small-cell lung cancer: final results from the open-label, phase 2 GEOMETRY mono-1 trial.

Background: Capmatinib has previously shown activity in treatment-naive and previously treated patients with non-small-cell lung cancer (NSCLC) and a MET exon 14-skipping mutation (METex14). Here, we report the final outcomes from the phase 2 GEOMETRY mono-1 study with an aim to provide further evidence for the activity of capmatinib.

Methods: In this non-randomised, multi-cohort, open-label, phase 2 trial conducted in 152 centres and hospitals in 25 countries, with patients treated in 95 centres in 20 countries, eligible patients (aged ≥18 years) with MET-dysregulated, EGFR wild-type, and ALK rearrangement-negative advanced NSCLC (stage IIIB/IV) and an Eastern Cooperative Oncology Group performance status of 0 or 1 were assigned to cohorts (1a, 1b, 2, 3, 4, 5a, 5b, 6 and 7) based on their MET status (METex14 or MET amplification) and previous therapy lines.

Microstructure and Mechanical Properties of NiTi Alloy Prepared by Double-Wire + Arc Additive Manufacturing Plus Heat Treatment.

In this study, NiTi shape memory alloy was prepared by double-wire + arc additive manufacturing plus heat treatment using TA1 and ER-Ni welding wires as the raw materials. The results show that the microstructural evolution from the bottom to top is NiTi + NiTi → NiTi + NiTi + NiTi → NiTi + NiTi + NiTi + NiTi + α-Ti. Complex thermal cycles led to the precipitation of NiTi, which improves the hardness of the matrix (B2), and the average hardness value of the top region reaches 550.

Synthesis of dithioacetals nucleophilic substitution and their antifungal activity evaluation.

A novel dual nucleophilic substitution reaction of dichloromethane with thiols has been developed, which affords dithioacetals in up to 96% yields. This dual substitution reaction with two different nucleophiles is also successfully developed with α-acyloxy sulfides as the product. In addition, antifungal activity tests against disclose that these α-acyloxy sulfides exhibit excellent antifungal activity with an inhibition rate up to 100 ± 0%.

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis.

JOURNAL/nrgr/04.03/01300535-202508000-00030/figure1/v/2024-09-30T120553Z/r/image-tiff Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell death. However, there is no effective treatment for retinitis pigmentosa caused by PDE6B mutation.

HM-chromanone attenuates obesity and adipose tissue inflammation by downregulating SREBP-1c and NF-κb pathway in high-fat diet-fed mice.

Obese adipose tissue produces various pro-inflammatory cytokines that are major contributors to adipose tissue inflammation. The present study aimed to determine the effects of HM-chromanone (HMC) against obesity and adipose tissue inflammation in high-fat diet-fed mice. Twenty-four C57BL/6J male mice were divided into three groups: ND (normal diet), HFD (high-fat diet), and HFD + HMC.

Comparison of three approaches for treating the bony access window in lateral sinus floor elevation: a retrospective analysis.

The aim of this study was to retrospectively determine the effects of applying different treatment methods to the bony access window on the healing outcomes in lateral sinus floor elevation (SFE). Lateral SFE with implant placement was performed in 131 sinuses of 105 patients. The following three treatment methods were applied to the bony access window: application of a collagen barrier (group CB), repositioning the bone fragment (group RW) and untreated (group UT).

Effect of food stimuli presentation on restrained eater's food choice: An ERP study.

Restrained eaters are individuals who consciously follow a limited food intake diet to lose or maintain body weight. With the rising numbers of obesity cases, retrained eating has became more prevalent as more people adopt it to cope with obesity. The dual conflict theory states that restrained eaters often encounter conflicting choices of food pleasure and weight management.

CoNi-layered double hydroxide derived CoS/NiS dodecahedron decorated with ReS Z-scheme heterojunction for efficient hydrogen evolution.

The high efficient utilization of light absorption and the effective separation of photogenerated carriers are critical factors in enhancing the performance of photocatalysts. In this study, CoNi-layered double hydroxide was synthesized using zeolitic imidazolate frameworks-67 as a template, followed by calcination to form CoS/NiS. Subsequently, ReS was deposited onto the surface of CoS/NiS, resulting in the ReS/CoS/NiS photocatalyst demonstrated notable hydrogen evolution activity under visible light, achieving a maximum hydrogen production rate of 40111.

Selective Functionalization of Alkenes and Alkynes by Dinuclear Manganese Catalysts.

ConspectusAlkenes and alkynes are fundamental building blocks in organic synthesis due to their commercial availability, bench-stability, and easy preparation. Selective functionalization of alkenes and alkynes is a crucial step for the synthesis of value-added compounds. Precise control over these reactions allows efficient construction of complex molecules with new functionalities.

Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.

The major female ovarian hormone, 17β-estradiol (E), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα.

Biocontrol mechanisms of poplar leaf blight due to Nigrospora oryzae.

Nigrospora oryzae, a newly identified pathogen, is responsible for poplar leaf blight, causing significant harm to poplar growth. Here, we describe, for the first time, a biological control method for the control of poplar leaf blight via the applications of 3 dominant Trichoderma strains/species. In this study, dominant Trichoderma species/strains with the potential for biocontrol were identified and then further characterised via dual culture assays, volatile organic compounds (VOCs), and culture filtrates.

Hyperplane tree-based data mining with a multi-functional memristive crossbar array.

This study explores the stochastic and binary switching behaviors of a Ta/HfO/RuO memristor to implement a combined data mining approach for outlier detection and data clustering algorithms in a multi-functional memristive crossbar array. The memristor switches stochastically with high state dispersion in the stochastic mode and deterministically between two states with low dispersion in the binary mode, while they can be controlled by varying operating voltages. The stochastic mode facilitates the parallel generation of random hyperplanes in a tree structure, used to compress spatial information of the dataset in the Euclidian space into binary format, still retaining sufficient spatial features.

Uncovering the decomposition mechanism of nitrate ester plasticized polyether (NEPE): a neural network potential simulation.

Nitrate ester plasticized polyether (NEPE) propellants have attracted widespread attention due to their high energy density and excellent low-temperature mechanical properties. However, little is known about the thermal decomposition process of the NEPE propellant, particularly lacking microscale models and interaction mechanisms. This work aims to establish a high-precision and efficient neural network potential (NNP) model covering the NEPE matrix, describing its mechanical behavior and detailed thermal decomposition mechanisms.

Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study.

Background: The role of smoking in the incidence of colorectal cancer (CRC) or gastric cancer (GC) in populations undergoing cholecystectomy has not been investigated.

Aim: To evaluate the effect of smoking on CRC or GC development in cholecystectomy patients.

Methods: A total of 174874 patients who underwent cholecystectomy between January 1, 2010 and December 31, 2017 were identified using the Korean National Health Insurance Service claims database.

Silibinin inhibits PM2.5-induced liver triglyceride accumulation through enhancing the function of mitochondrial Complexes I and II.

Background: The standardized extract of milk thistle seeds, known as silibinin, has been utilized in herbal medicine for over two centuries, with the aim of safeguarding the liver against the deleterious effects of various toxic substances. However, the role of silibinin in Particulate Matter (PM2.5)-induced intrahepatic triglyceride accumulation remains unclear.

Thresholding Computing with Heterogeneous Integration of Memristive Kernel with Metal-Oxide-Semiconductor Capacitor for Temporal Data Analysis.

Precise event detection within time-series data is increasingly critical, particularly in noisy environments. Reservoir computing, a robust computing method widely utilized with memristive devices, is efficient in processing temporal signals. However, it typically lacks intrinsic thresholding mechanisms essential for precise event detection.

Long-term follow-up of the TRED-HF trial: Implications for therapy in patients with dilated cardiomyopathy and heart failure remission.

Aims: In TRED-HF, 40% of patients with recovered dilated cardiomyopathy (DCM) relapsed in the short term after therapy withdrawal. This follow-up investigates the longer-term effects of therapy withdrawal.

Methods And Results: TRED-HF was a randomized trial investigating heart failure therapy withdrawal in patients with recovered DCM over 6 months.

Erosion degradation analysis of rice husk ash-rubber-fiber concrete under hygrothermal environment.

To study the resistance of rice husk ash-rubber-fiber reinforced concrete (RRFC) to dry-wet cycle/chloride erosion under a hygrothermal environment, the optimal combination was selected by an orthogonal test. The peak strain, residual strain, and fatigue damage strength of the optimal group of RRFC samples under cyclic loading and unloading after dry-wet cycle/chloride erosion under different environments and temperatures were compared and analyzed. After that, microscopic analysis and anti-erosion mechanism analysis were carried out.

Promising Approach for Optimizing Fluorescence Imaging in a Tumor Mouse Model: Precision in Cancer Research.

Background/aim: Cancer remains a major global health concern due to its high mortality rates. Advanced diagnostic imaging, such as in vivo near-infrared (NIR) fluorescence imaging, enhances early detection by reducing autofluorescence and enabling deeper tissue penetration, addressing some limitations of conventional methods. Understanding the underlying causes of autofluorescence, even in mouse model fluorescence imaging, is crucial for accurate interpretation.